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Table 3 Uni- and multivariate analysis using metabolic PET parameters and clinicopathologic factors for EFS

From: 18FDG-PET/CT for predicting the outcome in ER+/HER2- breast cancer patients: comparison of clinicopathological parameters and PET image-derived indices including tumor texture analysis

Parameters Univariate analysis Multivariate analysis
P value P value Hazard ratio (95% CI)
Age 0.10 Not included
Histology 0.02 0.02 3.80 (1.22–11.80)
Grade 0.60 Not included
PR expression 0.01 0.03 2.90 (1.12–7.49)
Tumor classification 0.09 Not included
Lymph node classification 0.24 Not included
Stage 0.05a Not included
SUVmax <0.01 Not retained in the final model
SUVmean 0.01 Not retained in the final model
SUVpeak <0.01 Not retained in the final model
MATV <0.01 <0.01 1.01 (1.00–1.02)b
TLG <0.01 Not retained in the final model
Entropy 0.02 Not retained in the final model
Homogeneity 0.02 Not retained in the final model
  1. P value corresponds to Cox proportional hazard regression model. Hazard ratios were calculated with their 95% confidence interval (CI). Bold numerals correspond to statistically significant P values
  2. PET positron emission tomography, EFS event-free survival, PR progesterone receptor, SUV standardized uptake value, MATV metabolically active tumor volume, TLG total lesion glycolysis, H homogeneity, E entropy
  3. aNot significant after multiple testing correction
  4. bHR for MATV was calculated on a continuous variable (if MATV increase from 1 ml, the risk of relapse increase of 1%)