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Table 3 Associations between tissue and blood levels of sex-steroid hormones measured, and presence of CLS among postmenopausal women with invasive breast cancer (n = 83)

From: Relationship between crown-like structures and sex-steroid hormones in breast adipose tissue and serum among postmenopausal breast cancer patients

 

Tissue (pg/g)

Blood (pg/ml)

  

Unadjusted

Adjusteda

  

Unadjusted

Adjusteda

CLS-positive

CLS-negative

OR

95% CI

OR

95% CI

CLS-positive

CLS-negative

OR

95% CI

OR

95% CI

Individual hormones

Androstenedione

 Tertile 3

7

21

Reference

Reference

7

21

Reference

Reference

 Tertile 2

10

17

1.77

0.84–8.07

1.67

0.47–5.93

11

16

2.06

0.65–6.51

0.46

0.13–1.62

 Tertile 1

13

15

2.60

0.84–8.07

3.13

0.88–11.18

12

16

2.25

0.72–7.01

0.95

0.28–3.20

  p trend

  

0.28

0.08

  

0.17

0.23

Testosterone

 Tertile 3

9

19

Reference

Reference

7

17

Reference

Reference

 Tertile 2

13

14

1.96

0.66–5.86

2.29

0.66–7.91

10

16

1.79

0.56–5.74

1.86

0.50–7.00

 Tertile 1

8

20

0.85

0.27–2.64

1.20

0.30–4.80

13

19

2.32

0.75–7.19

3.33

0.91–12.20

  p trend

  

0.78

0.70

  

0.15

0.07

Estrone

 Tertile 3

10

18

Reference

Reference

10

17

Reference

Reference

 Tertile 2

15

12

2.25

0.76–6.65

4.35

1.06–17.86

10

16

1.06

0.35–3.23

1.83

0.46–7.22

 Tertile 1

5

23

0.39

0.11–1.35

1.01

0.20–5.10

9

19

0.81

0.27–2.45

2.16

0.53–8.79

  p trend

  

0.17

0.90

  

0.70

0.29

Estradiol

 Tertiles 3

12

15

Reference

Reference

10

17

Reference

Reference

 Tertiles 2

9

18

0.63

0.21–1.88

0.69

0.20–2.39

8

14

0.97

0.30–3.12

1.41

0.38–5.30

 Tertiles 1

8

20

0.50

0.16–1.53

0.61

0.17–2.20

12

21

0.97

0.34–2.79

1.49

0.44–5.08

  p trend

  

0.22

0.46

  

0.96

0.53

Hormone ratios

Estrone:Androstenedione

 Tertiles 3

17

11

Reference

Reference

13

14

Reference

Reference

 Tertiles 2

9

18

0.32

0.11–0.97

0.30

0.08–1.17

10

17

0.63

0.21–1.88

1.00

0.29–3.47

 Tertiles 1

4

24

0.11

0.03–0.40

0.12

0.03–0.59

6

21

0.31

0.10–1.00

0.59

0.15–2.29

  p trend

  

<0.01

0.01

  

0.05

0.46

Estradiol:Testosterone

 Tertiles 3

12

16

Reference

Reference

17

12

Reference

Reference

 Tertiles 2

9

18

0.67

0.22–1.99

0.46

0.13–1.64

7

18

0.28

0.09–0.86

0.30

0.08–1.22

 Tertiles 1

8

19

0.56

0.18–1.71

0.38

0.10–1.39

6

21

0.20

0.06–0.65

0.18

0.04–0.72

  p trend

  

0.31

0.15

  

0.01

0.02

  1. Significant values are shown in bold
  2. aAdjusted for age, BMI, and fat area
  3. BMI body mass index, CI confidence interval, CLS crown-like structures, OR odds ratio
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Breast Cancer Research

ISSN: 1465-542X

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