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Table 3 Associations between tissue and blood levels of sex-steroid hormones measured, and presence of CLS among postmenopausal women with invasive breast cancer (n = 83)

From: Relationship between crown-like structures and sex-steroid hormones in breast adipose tissue and serum among postmenopausal breast cancer patients

  Tissue (pg/g) Blood (pg/ml)
   Unadjusted Adjusteda    Unadjusted Adjusteda
CLS-positive CLS-negative OR 95% CI OR 95% CI CLS-positive CLS-negative OR 95% CI OR 95% CI
Individual hormones
Androstenedione
 Tertile 3 7 21 Reference Reference 7 21 Reference Reference
 Tertile 2 10 17 1.77 0.84–8.07 1.67 0.47–5.93 11 16 2.06 0.65–6.51 0.46 0.13–1.62
 Tertile 1 13 15 2.60 0.84–8.07 3.13 0.88–11.18 12 16 2.25 0.72–7.01 0.95 0.28–3.20
p trend    0.28 0.08    0.17 0.23
Testosterone
 Tertile 3 9 19 Reference Reference 7 17 Reference Reference
 Tertile 2 13 14 1.96 0.66–5.86 2.29 0.66–7.91 10 16 1.79 0.56–5.74 1.86 0.50–7.00
 Tertile 1 8 20 0.85 0.27–2.64 1.20 0.30–4.80 13 19 2.32 0.75–7.19 3.33 0.91–12.20
p trend    0.78 0.70    0.15 0.07
Estrone
 Tertile 3 10 18 Reference Reference 10 17 Reference Reference
 Tertile 2 15 12 2.25 0.76–6.65 4.35 1.0617.86 10 16 1.06 0.35–3.23 1.83 0.46–7.22
 Tertile 1 5 23 0.39 0.11–1.35 1.01 0.20–5.10 9 19 0.81 0.27–2.45 2.16 0.53–8.79
p trend    0.17 0.90    0.70 0.29
Estradiol
 Tertiles 3 12 15 Reference Reference 10 17 Reference Reference
 Tertiles 2 9 18 0.63 0.21–1.88 0.69 0.20–2.39 8 14 0.97 0.30–3.12 1.41 0.38–5.30
 Tertiles 1 8 20 0.50 0.16–1.53 0.61 0.17–2.20 12 21 0.97 0.34–2.79 1.49 0.44–5.08
p trend    0.22 0.46    0.96 0.53
Hormone ratios
Estrone:Androstenedione
 Tertiles 3 17 11 Reference Reference 13 14 Reference Reference
 Tertiles 2 9 18 0.32 0.110.97 0.30 0.08–1.17 10 17 0.63 0.21–1.88 1.00 0.29–3.47
 Tertiles 1 4 24 0.11 0.030.40 0.12 0.030.59 6 21 0.31 0.101.00 0.59 0.15–2.29
p trend    <0.01 0.01    0.05 0.46
Estradiol:Testosterone
 Tertiles 3 12 16 Reference Reference 17 12 Reference Reference
 Tertiles 2 9 18 0.67 0.22–1.99 0.46 0.13–1.64 7 18 0.28 0.090.86 0.30 0.08–1.22
 Tertiles 1 8 19 0.56 0.18–1.71 0.38 0.10–1.39 6 21 0.20 0.060.65 0.18 0.040.72
p trend    0.31 0.15    0.01 0.02
  1. Significant values are shown in bold
  2. aAdjusted for age, BMI, and fat area
  3. BMI body mass index, CI confidence interval, CLS crown-like structures, OR odds ratio