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Table 2 Relation of clinicopathological characteristics with presence of CLS among postmenopausal women with invasive breast cancer (n = 83)

From: Relationship between crown-like structures and sex-steroid hormones in breast adipose tissue and serum among postmenopausal breast cancer patients

  CLS-positive n (%) CLS-negative n (%)   Unadjusted Adjustedb
Patient characteristic p valuea OR 95% CI OR 95% CI
Age    0.30     
 40–49 years 1 (3.3) 7 (13.0)   0.34 0.04–3.20 0.31 0.03–3.12
 50–59 years 8 (26.7) 19 (35.2)   Reference Reference
 60–69 years 12 (40.0) 18 (33.3)   1.68 0.55–5.08 1.17 0.35–3.91
 ≥70 years 9 (30.0) 10 (18.5)   2.14 0.63–7.26 1.63 0.45–6.00
BMI category    0.03     
 Lean 4 (14) 19 (36)   Reference Reference
 Overweight 13 (43) 23 (43)   2.69 0.75–9.61 1.93 0.50–7.40
 Obese 13 (43) 11 (21)   5.61 1.4621.53 4.63 1.0819.83
Age at menarche    0.28     
 <13 years 9 (31) 10 (19)   Reference Reference
 ≥13 years 20 (69) 43 (81)   0.52 0.18–1.47 0.40 0.12–1.32
Age at menopause    0.09     
 <45 years 2 (7) 6 (11)   Reference Reference
 45–49 years 8 (27) 25 (47)   0.96 0.16–5.74 1.50 0.21–10.44
 50–54 years 13 (43) 18 (34)   2.17 0.38–12.50 2.95 0.42–20.68
 ≥55 years 7 (23) 4 (8)   5.25 0.70–39.48 6.19 0.63–60.73
Age at first birth    1.00     
 Nulliparous 5 (17) 10 (19)   Reference Reference
 <30 years 20 (66) 35 (66)   1.14 0.34–3.82 1.08 0.28–4.17
 ≥30 years 5 (17) 8 (15)   1.25 0.27–5.89 1.42 0.26–7.93
Family history of breast cancer    0.53     
 No 24 (80) 46 (87)   Reference Reference
 Yes 6 (20) 7 (13)   1.64 0.50–5.44 2.91 0.71–11.96
Benign breast disease    0.74     
 No 25 (89) 44 (85)   Reference Reference
 Yes 3 (11) 8 (15)   0.66 0.16–2.72 1.09 0.22–5.35
Tumor size    1.00     
 ≤2 cm 15 (52) 26 (49)   Reference Reference
 >2 cm 14 (48) 27 (51)   0.90 0.36–2.22 0.62 0.22–1.75
Nodal status    0.22     
 No 20 (67) 26 (49)   Reference Reference
 1–3 7 (23) 15 (28)   0.61 0.21–1.77 0.38 0.11–1.41
 ≥4 3 (10) 12 (23)   0.33 0.08–1.31 0.44 0.10–2.00
ER status    0.80     
 Positive 21 (70) 39 (74)   Reference Reference
 Negative 9 (30) 14 (26)   1.19 0.44–3.22 1.09 0.35–3.39
PR status    0.80     
 Positive 21 (70) 39 (74)   Reference Reference
 Negative 9 (30) 14 (26)   1.19 0.44–3.22 1.09 0.35–3.39
Diagnosis    0.65     
 In situ and invasive 17 (57) 33 (62)   Reference Reference
 Invasive only 13 (43) 20 (38)   1.26 0.51–3.14 1.22 0.45–3.29
Grade    0.70     
 Well differentiated 4 (13) 11 (21)   Reference Reference
 Moderately differentiated 19 (64) 29 (55)   1.80 0.50–6.49 1.32 0.33–5.24
 Poorly differentiated 7 (23) 13 (24)   1.48 0.34–6.42 1.68 0.33–8.55
  1. aFisher's exact test. Significant values are shown in bold
  2. bAdjusted for age and BMI (age was adjusted for BMI only, BMI was adjusted for age only) and fat area
  3. BMI body mass index, CI confidence interval, CLS crown-like structures, ER estrogen receptor, OR odds ratio, PR progesterone receptor