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Table 2 Proportion of breast cancer cases followed versus the proportion of the general population at highest risk

From: Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry

PNF (%)

PCF (%)

 

PRS, SD = 0.38a

PRS, SD = 0.55b

1

2.6

3.8

5

10.3

13.7

10

18.4

23.2

20

32.2

38.5

30

44.3

51.0

40

55.0

61.7

50

64.8

70.9

60

73.7

78.9

70

81.7

85.9

80

88.9

91.8

90

95.2

96.6

95

97.9

98.6

99

99.7

99.8

  1. aObserved SD of the PRS distribution in East Asian women
  2. bAssumed SD of the PRS distribution, which corresponds to 30% of the heritability of breast cancer
  3. PCF proportion of cases followed, PNF proportion needed to follow-up, PRS polygenic risk score, SD standard deviation