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Table 3 Univariate analysis of risk factors associated with locoregional recurrence (n = 121 case-control pairs)

From: High mammographic breast density predicts locoregional recurrence after modified radical mastectomy for invasive breast cancer: a case-control study

  Control group Case group (all patients) Case group (only patients with LRR)    
  n = 121 n = 121 n = 43 HR 95% CI P value*
MBD quartiles       
 1, 2 (0– 50%) 82 69 26 1.0   
 3 (50– 75%) 32 41 13 3.1 1.1–9.8 0.043
 4 (75– 100%) 7 11 4 5.7 1.2–34.9 0.048
Tumor size (mm)       
 0–10 19 19 8 1.0   
 10 − 19 19 22 12 2.5 0.6–10.1 0.187
 20 − 50 68 63 15 1.8 0.2–3.8 0.806
 >50 15 17 8 4.1 0.3–57.5 0.291
Positive axillary nodes       
 None 47 49 15 1.0   
 1–3 32 32 12 0.6 0.1–2.5 0.477
 >4 42 40 16 0.8 0.1–6.4 0.731
Margin       
 Negative 112 106 37 1.0   
 Positive 9 15 6 3.3 1.3–8.3 0.010
Adjuvant chemotherapy       
 Yes 95 100 32 1.0   
 No 26 21 11 2.0 0.7–5.3 0.166
Adjuvant hormone therapy       
 Yes 74 71 22 1.0   
 No 47 50 21 2.0 0.2–22.1 0.571
Adjuvant target therapy       
 Yes 21 19 6 1.0   
 No 100 102 37 6.5 0.0–56.5 0.471
Adjuvant radiotherapy       
 Yes 62 57 20 1.0   
 No 59 64 23 1.6 0.6–3.9 0.120
Triple-negative cancer       
 Negative 100 95 34 1.0   
 Positive 21 26 9 2.0 0.5–8.0 0.327
BMI (kg/m2)       
 Normal (<25) 85 80 26 1.0   
 Overweight (25–30) 28 33 13 1.2 0.6–2.4 0.708
 Obese (>30) 8 10 4 1.1 0.3–3.8 0.931
  1. LRR locoregional recurrence, MBD mammographic breast density, BMI body mass index, HR hazard ratio, CI confidence interval. *Significance tested using conditional logistic regression analyses by stratified Cox model. P value <0.05 was considered statistically significant