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Table 3 Univariate analysis of risk factors associated with locoregional recurrence (n = 121 case-control pairs)

From: High mammographic breast density predicts locoregional recurrence after modified radical mastectomy for invasive breast cancer: a case-control study

 

Control group

Case group (all patients)

Case group (only patients with LRR)

   
 

n = 121

n = 121

n = 43

HR

95% CI

P value*

MBD quartiles

      

 1, 2 (0– 50%)

82

69

26

1.0

  

 3 (50– 75%)

32

41

13

3.1

1.1–9.8

0.043

 4 (75– 100%)

7

11

4

5.7

1.2–34.9

0.048

Tumor size (mm)

      

 0–10

19

19

8

1.0

  

 10 − 19

19

22

12

2.5

0.6–10.1

0.187

 20 − 50

68

63

15

1.8

0.2–3.8

0.806

 >50

15

17

8

4.1

0.3–57.5

0.291

Positive axillary nodes

      

 None

47

49

15

1.0

  

 1–3

32

32

12

0.6

0.1–2.5

0.477

 >4

42

40

16

0.8

0.1–6.4

0.731

Margin

      

 Negative

112

106

37

1.0

  

 Positive

9

15

6

3.3

1.3–8.3

0.010

Adjuvant chemotherapy

      

 Yes

95

100

32

1.0

  

 No

26

21

11

2.0

0.7–5.3

0.166

Adjuvant hormone therapy

      

 Yes

74

71

22

1.0

  

 No

47

50

21

2.0

0.2–22.1

0.571

Adjuvant target therapy

      

 Yes

21

19

6

1.0

  

 No

100

102

37

6.5

0.0–56.5

0.471

Adjuvant radiotherapy

      

 Yes

62

57

20

1.0

  

 No

59

64

23

1.6

0.6–3.9

0.120

Triple-negative cancer

      

 Negative

100

95

34

1.0

  

 Positive

21

26

9

2.0

0.5–8.0

0.327

BMI (kg/m2)

      

 Normal (<25)

85

80

26

1.0

  

 Overweight (25–30)

28

33

13

1.2

0.6–2.4

0.708

 Obese (>30)

8

10

4

1.1

0.3–3.8

0.931

  1. LRR locoregional recurrence, MBD mammographic breast density, BMI body mass index, HR hazard ratio, CI confidence interval. *Significance tested using conditional logistic regression analyses by stratified Cox model. P value <0.05 was considered statistically significant