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Table 1 Characteristics of the included cohorts

From: Propranolol and survival from breast cancer: a pooled analysis of European breast cancer cohorts

Country Breast cancer Medication data Mortality data Additionala confounders
source Diagnosis years source source End f-up Mean f-up (years) Max f-up (years) BC specific Grade Surg Radio Chemo Tam AI Asp/statin HRT Comorbidity
Belgium Belgian Cancer Registry 2007–2009 Intermutualistic Agency (health insurance records) Kruispuntbank van de Sociale Zekerheid (social security records) 2014 6 8 No Yes Yes Yes Yes Yes Yes Yes Yes No
Denmark Danish Cancer Registryb 2000–2012 Danish National Prescription Registry Danish Civil Registration System 2012 6 13 No Yes Yes Yes Yes Yes Yes Yes Yes Yesc
England (UK) National Cancer Data Repository 1998–2007 CPRD (GP records) Office of National Statistics 2011 6 12 Yes Yes Yes Yes Yes Yes Yes Yes No Yesd
The Netherlands Eindhoven Cancer Registry 1999–2011 PHARMO (pharmacy records) Central Bureau of Genealogy 2012 6 13 No Yes Yes Yes Yes Yes Yes Yes Yes Yesg
Northern Ireland (UK) Northern Ireland Cancer Registry 2009–2010 NIEPD (electronic dispensing database) General Register Office for Northern Ireland 2013 4 5 Yes No Yes N Yes Yes Yes Yes No No
Republic of Ireland National Cancer Registry Ireland 2001–2010 GMSe (electronic prescribing database) Central Statistics Office (Death Certificates) 2012 5 11 Yes Yes Yes Yes Yes Yes Yes Yes Yes Yesf
Scotland (UK) Scottish Cancer Registry 2009–2012 Prescribing Information System (electronic dispensing database) National Records of Scotland Death Records 2015 4 6 Yes Yes Yes Yes Yes Yes Yes Yes No Yesc
Sweden Regional cancer registries in Norra, Uppsala/Örebro Stockholm/Gotland 2007–2012 The Prescribed Drug Register Cause of death registry 2012 4 6 Yes Yes Yes Yes Yes Yes Yes Yes Yes Yesc
  1. aIn fully adjusted analyses (presented in Tables 2 and 3), the model contains age at diagnosis, year of diagnosis, stage and the variables shown
  2. bOnly including stages 1–3
  3. cBased on hospital admissions
  4. dBased on GP diagnosis codes
  5. eGMS includes eligible patients based upon means test and age (all patients over 70 years old are included)
  6. fBased on RxRisk comorbidity score
  7. gFrom cancer registry records
  8. AI aromatase inhibitors, asp aspirin, BC breast cancer, chemo chemotherapy, CPRD clinical practice research datalink, f-up follow-up duration from diagnosis to death or censoring, GMS General Medical Services scheme, GP general practitioner, HRT hormone replacement therapy, max maximum, NIEPD Northern Ireland Electronic Prescribing Database, radio radiotherapy, surg surgery, tam tamoxifen