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Fig. 7 | Breast Cancer Research

Fig. 7

From: The AF-1-deficient estrogen receptor ERα46 isoform is frequently expressed in human breast tumors

Fig. 7

Possible mechanisms to generate the estrogen receptor alpha (ERα)46 and epitope mapping of the antibodies used in this work. ERα46 can be generated either by alternative splicing of the first coding exon [16], by internal ribosomal entry site (IRES)-dependent translation from the full-length ESR1 transcript [14], or by proteolysis of ERα66 by as-yet unknown proteases [15]. It should be emphasized that these three different mechanisms could concur to generate the ERα46 isoform, which, to the best of our knowledge, is a unique feature among proteins. AF activation function, DBD DNA-binding domain, H Hinge domain, LBD ligand-binding domain

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