Fig. 4
From: The AF-1-deficient estrogen receptor ERα46 isoform is frequently expressed in human breast tumors
Estrogen receptor alpha (ERα)46 antagonizes the 17β-estradiol (E2) proliferative response of ERα66 in MCF7 cells. a Expression of the ERα46 and ERα66 proteins on MCF7 clones analyzed by Western blotting following tetracycline (tet) treatment to induce the ERα46 expression. b The proliferative effect of E2 was then analyzed by counting cells after 5 days of stimulation with 10 nM E2. ***P < 0.001. ns not significant