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Table 3 The top 15 of 46 analyzed features were significant (p < 0.05) in the case–control models

From: Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status

Feature

All five studies OR (95% CI)

p value

AUCa

MMHS OR (95% CI)

MCMAM OR (95% CI)

SFMR OR (95% CI)

NHS OR (95% CI)

NHSII OR (95% CI)

N case/N control

1171/1659

  

62/112

242/395

104/206

412/454

351/492

FD_TH_75

0.87 (0.79–0.95)

0.003

0.621

0.76 (0.48–1.20)

0.73 (0.56–0.94)*

1.28 (0.90–1.82)

0.94 (0.80–1.11)

0.84 (0.72–0.98)*

Energy

0.88 (0.81–0.96)

0.003

0.621

1.03 (0.71–1.51)

0.84 (0.70–1.01)

1.35 (0.97–1.89)

0.85 (0.73–0.98)*

0.86 (0.73–1.00)

Entropy

1.14 (1.05–1.25)

0.003

0.620

1.01 (0.68–1.51)

1.30 (1.06–1.59)*

0.75 (0.54–1.04)

1.19 (1.02–1.38)*

1.13 (0.96–1.32)

FD_TH_70

0.87 (0.79–0.96)

0.005

0.621

0.88 (0.55–1.43)

0.72 (0.55–0.94)*

1.28 (0.87–1.87)

0.97 (0.82–1.15)

0.82 (0.70–0.96)*

FD_TH_80

0.89 (0.82–0.98)

0.012

0.620

0.86 (0.56–1.31)

0.88 (0.70–1.12)

1.17 (0.84–1.64)

0.90 (0.77–1.06)

0.87 (0.75–1.01)

FD_TH_10

1.11 (1.02–1.20)

0.015

0.620

1.43 (1.00–2.06)

1.11 (0.92–1.34)

1.07 (0.80–1.42)

1.03 (0.89–1.19)

1.15 (0.98–1.34)

Kurtosis

0.89 (0.81–0.98)

0.015

0.620

0.91 (0.61–1.34)

0.85 (0.69–1.06)

0.84 (0.60–1.16)

0.86 (0.74–1.01)

0.95 (0.80–1.12)

FD_TH_65

0.88 (0.80–0.98)

0.016

0.620

0.95 (0.57–1.58)

0.78 (0.59–1.04)

1.50 (0.98–2.29)

0.97 (0.82–1.15)

0.81 (0.68–0.96)*

FD_Minkowski

0.88 (0.79–0.98)

0.017

0.621

0.65 (0.34–1.24)

0.85 (0.67–1.09)

1.07 (0.72–1.59)

0.84 (0.70–1.00)*

0.91 (0.74–1.13)

Busyness

1.10 (1.02–1.20)

0.019

0.619

1.43 (0.97–2.13)

1.17 (0.97–1.41)

1.00 (0.74–1.35)

0.99 (0.86–1.15)

1.18 (1.02–1.38)*

Homogeneity

1.10 (1.01–1.20)

0.023

0.620

1.43 (0.95–2.14)

0.92 (0.76–1.13)

1.38 (1.00–1.90)

1.09 (0.94–1.26)

1.18 (1.01–1.37)*

Dissimilarity

0.91 (0.83–0.99)

0.033

0.620

0.72 (0.48–1.09)

1.10 (0.90–1.34)

0.74 (0.53–1.03)

0.92 (0.79–1.06)

0.85 (0.73–0.99)*

FD_TH_60

0.89 (0.80–0.99)

0.035

0.620

1.02 (0.60–1.73)

0.74 (0.55–0.98)*

1.49 (0.95–2.33)

1.00 (0.83–1.19)

0.82 (0.68–0.98)*

FD_TH_85

0.92 (0.84–1.00)

0.046

0.619

0.98 (0.65–1.46)

0.89 (0.71–1.11)

1.12 (0.82–1.53)

0.93 (0.79–1.08)

0.90 (0.78–1.05)

FD_TH_15

1.09 (1.00–1.18)

0.048

0.619

1.42 (0.96–2.11)

1.09 (0.91–1.31)

1.04 (0.79–1.39)

0.96 (0.83–1.11)

1.21 (1.04–1.42)*

  1. Features listed in italics were significant in at least two studies.
  2. Results are presented as odds ratio (OR) and 95% confidence interval (CI) per 1 standard deviation in normalized feature after adjustment for age, body mass index (BMI), family history, percent density (PD), and study.
  3. aAdjusted for age, BMI, family history, PD, and study. Area under the curve (AUC) for the adjustment factors only is 0.617 (95% CI 0.596–0.638)
  4. *Study p values < 0.05.
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Breast Cancer Research

ISSN: 1465-542X

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