|  |  | Univariate model | Multivariableb model | Multivariablec model | |||
---|---|---|---|---|---|---|---|---|
Gene: SNP | Comparisons | Numbera (events) | Odds ratio (95Â % CI) | P value | Odds ratio (95Â % CI) | P value | Odds ratio (95Â % CI) | P value |
Hot flashes/sweating | ||||||||
  CYP19A1: rs4646 | Dose effectd | 1965 (848) | 1.05 (0.91,1.21) | 0.50 | 1.04 (0.90,1.20) | 0.63 | 1.08 (0.93,1.25) | 0.30 |
  CYP19A1: rs10046 | T/T vs. C/T,C/C (ref) | 446 (172) vs. 1519 (676) | 0.78 (0.63,0.97) | 0.03 | 0.82 (0.66,1.02) | 0.08 | 0.83 (0.66,1.04) | 0.10 |
  ESR1:rs2077647 | Dose effect | 1965 (848) | 0.95 (0.84,1.08) | 0.47 | 0.96 (0.84,1.09) | 0.51 | 0.97 (0.85,1.11) | 0.69 |
  ESR1:rs2234693 (PvuII) | Dose effect | 1965 (848) | 0.92 (0.80,1.04) | 0.18 | 0.92 (0.80,1.04) | 0.19 | 0.94 (0.82,1.07) | 0.36 |
  ESR1:rs9340799 (XbaI) | Dose effect | 1965 (848) | 0.94 (0.82,1.08) | 0.38 | 0.94 (0.82,1.07) | 0.34 | 0.98 (0.85,1.12) | 0.73 |
Musculoskeletal symptoms | ||||||||
  CYP19A1: rs4646 | Dose effectd | 1966 (516) | 1.01 (0.86,1.18) | 0.90 | 1.05 (0.89,1.24) | 0.55 | 1.11 (0.93,1.31) | 0.25 |
  CYP19A1: rs10046 | T/T vs. C/T,C/C (ref) | 446 (110) vs. 1520 (406) | 0.90 (0.70,1.15) | 0.39 | 0.86 (0.66,1.10) | 0.23 | 0.84 (0.65,1.09) | 0.18 |
  ESR1:rs2077647 | Dose effect | 1966 (516) | 1.08 (0.94,1.25) | 0.28 | 1.12 (0.96,1.30) | 0.15 | 1.11 (0.95,1.29) | 0.20 |
  ESR1:rs2234693 (PvuII) | Dose effect | 1966 (516) | 1.03 (0.90,1.19) | 0.65 | 1.07 (0.92,1.25) | 0.37 | 1.06 (0.91,1.24) | 0.47 |
  ESR1:rs9340799 (XbaI) | Dose effect | 1966 (516) | 1.06 (0.91,1.23) | 0.44 | 1.10 (0.94,1.29) | 0.22 | 1.11 (0.94,1.30) | 0.22 |