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Table 2 Minor allele frequency and genotype of the five genotyped SNPs in CYP19A1 and ESR1

From: Impact of CYP19A1 and ESR1 variants on early-onset side effects during combined endocrine therapy in the TEXT trial

     Genotype, n (%)  
Gene SNP Number assessed Minor allele frequency Wild-type Heterozygous Homozygous HWE P value
CYP19A1 rs4646 (G > T) 1967 0.29 989 (50) 822 (42) 156 (8) 0.44
CYP19A1 rs10046 (C > T) 1967 0.48 532 (27) 989 (50) 446 (23) 0.75
ESR1 rs2077647 (A > G) 1967 0.47 550 (28) 999 (51) 418 (21) 0.39
ESR1 rs2234693 (Pvull) (T > C) 1967 0.45 594 (30) 993 (50) 380 (19) 0.36
ESR1 rs9340799 (Xbal) (A > G) 1967 0.36 806 (41) 923 (47) 238 (12) 0.30
  1. CYP19A1 Cytochrome P450 19A1, ESR1 Estrogen receptor 1, HWE Hardy-Weinberg equilibrium, SNP single nucleotide polymorphism