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Table 2 Relationship between nuclear ADA3 and nuclear c-MYC co-expression groups and clinico-pathological parameters within the whole unselected invasive breast cancer series (n = 588 cases)

From: ADA3 regulates normal and tumor mammary epithelial cell proliferation through c-MYC

Parameters ADA3 Nuclear c-MYC Nuclear expression phenotypes
ADA3low c-MYClow
N (%)
ADA3high c-MYClow
N (%)
ADA3low c-MYChigh
N (%)
ADA3high c-MYChigh
N (%)
X 2 P
Patient age ≤50 66 (31.7) 24 (11.5) 65 (31.1) 53 (25.5) 1.862 0.602
>50 106 (28.0) 45 (11.9) 113 (29.8) 115 (30.3)
Menopausal Status Pre 66 (30.4) 25 (11.5) 68 (31.3) 58 (26.7) 0.907 0.871
Post 106 (28.6) 44 (11.9) 110 (29.7) 110 (29.7)
Tumor size ≤2 cm 96 (28.0) 14 (12.0) 99 (28.9) 107 (31.2) 2.765 0.429
>2 cm 76 (31.4) 28 (11.6) 77 (31.8) 61 (25.2)
Tumor grade 1 20 (23.5) 14 (16.6) 17 (20.0) 34 (40.0) 32.961 <0.001
2 47 (25.3) 18 (9.7) 48 (25.8) 73 (39.2)
3 105 (33.3) 37 (11.7) 112 (35.4) 62 (19.6)
Tubules 1 5 (22.7) 7 (31.8) 5 (22.7) 5 (22.7) 13.345 0.037
2 47 (25.1) 21 (11.2) 59 (31.6) 60 (32.1)
3 116 (32.7) 35 (9.9) 107 (30.1) 97 (27.3)
Pleomorphism 1 1 (14.3) 1 (14.3) 3 (42.9) 2 (28.6) 29.138 <0.001
2 57 (26.0) 31 (14.2) 46 (21.0) 85 (38.8)
3 110 (32.6) 31 (9.2) 122 (36.2) 74 (22.0)
Mitosis 1 43 (24.6) 23 (13.1) 40 (22.9) 69 (39.4) 23.706 0.001
2 30 (29.1) 9 (8.7) 30 (29.1) 34 (33.0)
3 95 (33.2) 31 (10.8) 101 (35.3) 59 (20.6)
Axillary nodal stage 1 93 (28.5) 42 (12.9) 90 (27.6) 101 (31.0) 6.617 0.353
2 57 (28.2) 23 (11.4) 68 (33.7) 54 (26.7)
3 22 (37.3) 4 (6.8) 20 (33.9) 13 (22.0)
NPI Good 30 (19.2) 21 (13.5) 39 (4) 66 (25.0) 33.968 <0.001
Moderate 103 (33.0) 40 (12.8) 88 (8.8) 81 (28.2)
Poor 39 (33.1) 8 (6.8) 50 (36) 21 (17.8)
Lymphovascular Invasion Negative 106 (28.0) 52 (13.8) 103 (27.2) 117 (31.0) 10.624 0.014
Positive 64 (31.4) 16 (7.8) 75 (36.8) 49 (24.0)
Tumor type Invasive Ductal/NST 123 (34.6) 39 (11.0) 120 (33.7) 74 (20.8) 61.858 <0.001
Invasive Lobular 13 (22.4) 8 (13.8) 4 (6.9) 33 (56.9)
Medullary-like 2 (11.1) 3 (16.7) 9 (50.0) 4 (22.2)
Excellent Prognostic Special types* 5 (25.0) 6 (30.0) 5 (25.0) 4 (20.0)
Tubular Mixed 20 (20.6) 11 (11.3) 28 (28.9) 38 (39.2)
Mixed NST & Lobular 4 (19.0) 2 (9.5) 6 (28.6) 9 (42.9)
Mixed NST &other special types 2 (25.0) 0 3 (37.5) 3 (37.5)
  1. N = number of cases. c. = cytoplasmic, n. = nuclear expression. NST = No Special Type. NPI = Nottingham Prognostic Index
  2. Analysis of all patient specimens from the unselected invasive breast cancer cohort demonstrates a significant correlation between nuclear ADA3 and c-MYC levels in the areas of tumor grade, pleomorphism, tubule formation, mitotic scores, NPI, and tumor type across the four groups
  3. The bold font indicate that the clinical correlation is statistically significant < 0.05
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