Table 2 Description of BRCA1, BRCA2, and transheterozygote BRCA1 + BRCA2 mutation carriers
Variable | Value | BRCA1 + BRCA2 (TH)N(%) | BRCA1 (SH1)N(%) | P value* | P value* | BRCA1 + BRCA2 (TH) N(%) | BRCA2 (SH2)N(%) | P value** | P value** |
|---|---|---|---|---|---|---|---|---|---|
Total matched | 91 | 9316 | 89 | 3370 | |||||
Year of birth | <1940 1941–1950 1951–1960 1961–1970 >1970 | 5 (5.5) 20 (22.0) 21 (22.6) 27 (29.0) 18 (19.8) | 886 (9.5) 1628 (17.4) 2607 (28.0) 2409 (25.9) 1779 (19.0) | 0.424 | (ref) 0.112 0.474 0.153 0.245 | 5 (5.6) 19 (21.3) 19 (21.3) 27 (30.3) 19 (21.3) | 486 (14.4) 735 (21.8) 914 (27.1) 724 (21.5) 511 (15.2) | 0.025 | (ref) 0.060 0.156 0.005 0.007 |
Ethnicity | White African American Asian Hispanic Jewish Other | 47 (51.6) 0 (0) 6 (6.6) 1 (1.1) 30 (33.0) 7 (7.7) | 5736 (61.6) 20 (0.2) 82 (0.9) 143 (1.5) 1779 (19.1) 1556 (16.7) | <0.001 | (ref) 1.00* <0.001 1.00 0.002 -- | 45 (50.6) 0 (0) 6 (6.7) 2 (2.2) 29 (32.6) 7 (7.9) | 1686 (50.0) 15 (0.4) 66 (2.0) 57 (1.7) 936 (27.8) 610 (18.1) | 0.007 | (ref) 1.00* 0.004 0.667 0.573 -- |
Breast cancer | No Yes | 29 (31.9) 62 (68.1) | 4470 (48.0) 4846 (52.0) | 0.002 | 29 (32.6) 60 (67.4) | 1671 (49.6) 1699 (50.4) | 0.002 | ||
Age of breast cancer | Mean (range) | 40.4 (23–67) | 41.9 (18–82) | 0.231 | 40.5 (23–67) | 45.0 (19–82) | <0.001 | ||
Ovarian cancer | No Yes | 74 (81.3) 17 (18.7) | 7766 (83.4) 1550 (16.6) | 0.603 | 74 (83.1) 15 (16.9) | 3056 (90.7) 314 (9.3) | 0.017 | ||
Age of ovarian cancer | Mean (range) | 54.1 (36–66) | 50.9 (20–85) | 0.154 | 54.7 (42–66) | 56.8 (26–89) | 0.421 | ||
Bilateral mastectomy | No Yes | 58 (63.7) 8 (9.0) | 4807 (51.6) 809 (8.7) | 0.599 | 58 (65.2) 8 (9.0) | 1856 (55.0) 305 (9.1) | 0.646 | ||
Prophylactic oophorectomy | No Yes | 45 (49.5) 24 (26.4)) | 3583 (38.4) 2476 (26.6) | 0.307 | 45 (50.6) 24 (27.0) | 1388 (41.2) 980 (29.1) | 0.272 | ||
Follow up age (if no cancer) | Mean (range) | 39.1 (20–68) | 40.5 (18–99) | 0.587 | 39.1 (20–68) | 44.1 (18–94) | 0.068 |