Fig. 2

Quantitative analysis of the histopathological results of chamber material. a–d Representative photomicrographs of the various numerical categories used to score human breast histopathology observed in biochambers. a Category 0, the absence of DCIS and cancer and the presence of fatty normal breast tissue. b Category 0, the absence of DCIS and cancer and the presence of dense normal breast tissue. c Category 1, high-grade DCIS only. d Category 2-3, grade 3 invasive carcinoma. e The numerical histological categories 0–3 included a breakdown of the presence of high-grade DCIS alone or along with a certain percentage of grade 3 IDC. The mean histological category for the chamber explants for each of the ten women according to the type of input material. f Average values for each woman for the histological category of the chamber material. HMD High mammographic density, LMD Low mammographic density, DCIS MCF10DCIS.com cells, IDC Invasive ductal carcinoma. *P = 0.004; **P = 0.002. All bar and scatterplot graphs represent mean ± SEM