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Table 3 Univariate (partially adjusted) and multivariate (fully adjusted) hazard ratio (HR) and 95 % CI for the associations between automated and visual KI67 scores with survival in breast cancer (N = 2440)

From: Prognostic value of automated KI67 scoring in breast cancer: a centralised evaluation of 8088 patients from 10 study groups

 

Partially adjusted modela

Fully adjusted modelb

Visual

Automated

Visual

Automated

Patients (N)

Deaths (N)

HR (95 % CI)

P value

Patients (N)

Deaths (N)

HR (95 % CI)

P value

HR (95 % CI)

P value

HR (95 % CI)

P value

Overall

 Low KI67

1804

116

1.00 (referent)

 

1728

125

1.00 (referent)

 

1.00 (referent)

 

1.00 (referent)

 

 High KI67

636

78

2.40 (1.92–3.01)

2.20 × 10−14

712

69

1.67 (1.33–2.10)

1.30 × 10−5

1.75 (1.23–2.49)

0.002

1.61 (1.14–2.28)

0.007

 AICc

  

5050.4

   

5087.2

     

 BICc

  

5090.8

   

5127.6

     

ER-positive

 Low KI67

1,337

69

1.00 (referent)

 

1241

69

1.00 (referent)

 

1.00 (referent)

 

1.00 (referent)

 

 High KI67

282

27

2.40 (1.72–3.33)

2.00 × 10−7

378

27

1.47 (1.05–2.04)

0.024

2.30 (1.34–3.94)

0.002

2.10 (1.28–3.47)

0.004

 AIC

  

2618.8

   

2638.2

     

 BIC

  

2656.8

   

2675.8

     

ER-negative

 Low KI67

357

39

1.00 (referent)

 

392

48

1.00 (referent)

 

1.00 (referent)

 

1.00 (referent)

 

 High KI67

331

48

1.84 (1.30–2.62)

6.10 × 10−4

296

39

1.44 (1.02–2.04)

0.043

1.62 (0.97–2.72)

0.066

1.28 (0.79–2.05)

0.312

 AIC

  

1755.7

   

1763.4

     

 BIC

  

1787.4

   

1795.1

     
  1. aPartially adjusted model—adjusted for age at diagnosis and study group only
  2. bFully adjusted model—further adjustment for other prognostic factors including histological grade, tumour size, nodal status, ER, PR, HER2, morphological subtype and systemic therapy (endocrine and/or chemotherapy). This model was based on 20 imputations performed to address missing values on other covariates
  3. cModel fit parameter
  4. AIC Akaike information criterion, BIC Bayesian information criterion, ER oestrogen receptor, HR hazard ratio, HER2 human epidermal growth factor receptor 2, PR progesterone receptor