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Table 3 Standardized incidence ratio (SIR) of second invasive breast cancer (ipsilateral and contra lateral) after diagnosis of first in situ breast cancer, by year at first diagnosis, age at first diagnosis, time since first diagnosis and family history (years)

From: The impact of in situ breast cancer and family history on risk of subsequent breast cancer events and mortality - a population-based study from Sweden

  All No family history Family history
Number SIR 95 % CI Number SIR 95 % CI Number SIR 95 % CI
Calendar yeara
 1980–1984 81 3.3 2.6–4.1 72 3.1 2.4 − 3.9 9 6.6 3.0–12.5
 1985–1989 141 3.5 3.0 − 4.2 123 3.4 2.8–4.0 18 5.3 3.2–8.4
 1990–1994 292 5.2 4.6 − 5.9 259 5.1 4.5–5.8 33 5.9 4.1–8.3
 1995–1999 182 5.2 4.5 − 6.1 160 5.2 4.4–6.0 22 5.2 3.3–7.9
 2000–2004 72 5.1 4.0 − 6.4 63 5.1 3.9–6.5 9 5.5 2.5–10.4
P value <0.001    <0.001    1  
Age at diagnosis (years)
  < 40 39 8.5 6.0–11.7 27 7.2 4.8–10.5 12 14.3 7.4–25.0
 40–49 173 4.9 4.2–5.7 147 4.8 4.1–5.71 26 4.7 3.1–6.8
 50–59 221 4.1 3.6–4.6 189 3.9 3.4–4.5 32 5.2 3.6–7.4
 60–69 220 4.6 4.0–5.2 207 4.5 (4.0–5.2) 13 5.2 2.8–8.8
  ≥ 70 115 4.3 3.6–5.2 107 4.2 (3.4–5.1) 8 6.9 3.0–13.6
P trend 0.008    0.069    0.096  
  < 40 39 8.5 6.1–11.7 27 7.2 4.8–10.5 12 14.3 7.4–25.0
  > 40 729 4.4 4.1–4.8 650 4.3 4.0–4.7 79 5.2 4.1–6.4
P value <0.001    0.012    0.001  
Time since diagnosis (years)
 0–4 401 5.2 4.7–5.7 359 5.1 4.6–5.7 42 5.5 3.9–7.3
 5–9 230 4.4 3.9–5.1 197 4.2 3.6–4.8 33 6.5 4.5–9.2
 10–14 96 3.4 2.8–4.2 85 3.3 2.6–4.1 11 4.3 2.1–7.7
  > 15 41 3.4 2.4–4.6 36 3.2 2.2–4.4 5 5.9 1.9–13.8
P trend <0.001    <0.001    0.848  
  1. aOn restriction of the follow-up time to 5 years the estimates were similar but the trend tests not significant