(a) All breast cancer patients | Univariate analysis | Adjusted analysis | ||||
I157T/nc | I157T/1100delC | 1100delc/nc | I157T/nc | I157T/1100delC | 1100delC/nc | |
Early death | 0.85 [0.68 - 1.07] | 0.74 [0.50 - 1.09] | 1.28 [1.00 - 1.64] | 0.80 [0.60 - 1.07] | 0.51 [0.29 - 0.90] | 1.32 [0.94 - 1.86] |
0.16 | 0.12 | 0.054 | 0.13 | 0.0190 | 0.11 | |
Breast cancer-specific death | 0.85 [0.60 - 1.20] | 0.64 [0.37 - 1.12] | 1.44 [1.04 - 2.00] | 0.93 [0.62 - 1.40] | 0.46 [0.21 - 1.03] | 1.25 [0.78 - 2.00] |
0.36 | 0.12 | 0.030 | 0.73 | 0.058 | 0.36 | |
Distant metastasis relapse | 1.04 [0.79 - 1.37] | 0.66 [0.38 - 1.14] | 1.38 [0.90 - 2.11] | 1.05 [0.75 - 1.47] | 0.62 [0.31 - 1.23] | 1.37 [0.83 - 2.26] |
0.79 | 0.13 | 0.14 | 0.76 | 0.17 | 0.22 | |
Locoregional relapse | 1.43 [0.92 - 2.23] | 0.81 [0.58 - 1.13] | 2.07 [1.16 - 3.69] | 1.62 [0.99 - 2.66] | 0.91 [0.33 - 2.52] | 1.26 [0.59 - 2.70] |
0.11 | 0.21 | 0.014 | 0.056 | 0.85 | 0.55 | |
Second breast cancer | 1.54 [0.85 - 2.78] | 0.69 [0.47 - 1.03] | 2.88 [1.68 - 4.98] | 2.03 [1.05 - 3.92] | 0.69 [0.42 - 1.13] | 3.62 [1.82 - 7.21] |
0.15 | 0.070 | 0.00015 | 0.035 | 0.14 | 0.00026 | |
(b) Patients with ER+ breast cancer | Univariate analysis | Adjusted analysis | ||||
I157T/nc | I157T/1100delC | 1100delc/nc | I157T/nc | I157T/1100delC | 1100delC/nc | |
Early death | 0.81 [0.61 - 1.07] | 0.62 [0.39 - 0.99] | 1.32 [0.98 - 1.78] | 0.77 [0.55 - 1.07] | 0.46 [0.25 - 0.85] | 1.52 [1.06 - 2.17] |
0.14 | 0.044 | 0.067 | 0.12 | 0.013 | 0.022 | |
Breast cancer-specific death | 0.80 [0.51 - 1.23] | 0.47 [0.23 - 0.96] | 1.46 [0.96 - 2.22] | 0.80 [0.49 - 1.32] | 0.33 [0.13 - 0.84] | 1.50 [0.92 - 2.45] |
0.30 | 0.038 | 0.074 | 0.39 | 0.019 | 0.10 | |
Distant metastasis relapse | 1.00 [0.71 - 1.40] | 0.55 [0.29 - 1.02] | 1.58 [0.99 - 2.54] | 1.03 [0.70 - 1.51] | 0.56 [0.26 -1.19] | 1.61 [0.94 - 2.77] |
0.98 | 0.057 | 0.056 | 0.88 | 0.13 | 0.083 | |
Locoregional relapse | 1.46 [0.86 - 2.47] | 0.77 [0.52 - 1.14] | 2.33 [1.19 - 4.57] | 1.58 [0.90 - 2.79] | 0.93 [0.29 - 2.98] | 1.08 [0.44 - 2.66] |
0.16 | 0.19 | 0.014 | 0.11 | 0.90 | 0.87 | |
Second breast cancer | 1.33 [0.64 - 2.75] | 0.58 [0.37 - 0.92] | 4.09 [2.31 - 7.26] | 1.81 [0.82 - 3.96] | 0.61 [0.36 - 1.04] | 4.39 [2.17 - 8.87] |
0.44 | 0.019 | 1.4E-06 | 0.14 | 0.067 | 3.8E-05 | |
(c) Patients with lobular breast cancer | Univariate analysis | |||||
I157T/nc | ||||||
Early death | 0.67 [0.39 - 1.15] | |||||
0.14 | ||||||
Breast cancer-specific death | 0.91 [0.46 - 1.80] | |||||
0.79 | ||||||
Distant metastasis relapse | 0.87 [0.48 - 1.57] | |||||
0.64 | ||||||
Locoregional relapse | 2.45 [0.95 - 6.34] | |||||
0.065 | ||||||
Second breast cancer | 1.92 [0.57 - 6.49] | |||||
0.29 |