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Fig. 5 | Breast Cancer Research

Fig. 5

From: Low expression of galectin-3 is associated with poor survival in node-positive breast cancers and mesenchymal phenotype in breast cancer stem cells

Fig. 5

Low galectin-3 (Gal3) correlates with heightened tumorigenicity. a GI-LM2C (red) and GI-LM2G (green) sphere cells were injected into the fourth mammary fat pad of mice with rapid tumor growth in GI-LM2G (upper panel) (n ≥ 3). A representative picture of mice used in this study is shown (red arrow = injection site for GI-LM2C; green arrow = injection site for GI-LM2G). b In vivo tumorigenicity assay with limited dilution; shown are the tumor-free survival curves for 10,000 (left), 1000 (middle), and 100 (right) injected cells (GI-LM2C (red) and GI-LM2G (green)). c Sections of the tumor specimens from experiments in (a) and (b) were stained for hematoxylin and eosin (H&E), Gal3 (IHC), and Gal3 IF (to the left, GI-LM2C, to the right GI-LM2G)

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Breast Cancer Research

ISSN: 1465-542X

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