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Table 3 Cumulus and LIBRA mammographic density measurements and breast cancer risk, by type of digital image

From: Impact of type of full-field digital image on mammographic density assessment and breast cancer risk estimation: a case-control study

 

Cumulus

LIBRA

Raw images

Processed images

Analogue-like images

Raw images

Processed images

N

ORa (95 % CI)

N

ORa (95 % CI)

N

ORa (95 % CI)

N

ORa (95 % CI)

N

ORa (95 % CI)

Percent density (%)

 All readingsb

952

1.35 (1.14,1.60)

863

1.55 (1.29,1.85)

951

1.52 (1.28,1.80)

952

1.17 (0.99,1.37)

863

1.32 (1.08,1.61)

 Multiple imputationb,c

1098

1.58 (1.46,1.70)

998

1.91 (1.76,2.08)

1097

1.93 (1.78,2.09)

1098

1.21 (1.12,1.32)

998

1.65 (1.49,1.82)

 Restricted to women aged <80 yearsb

899

1.35 (1.13,1.60)

811

1.54 (1.28,1.85)

898

1.54 (1.29,1.83)

899

1.18 (1.01,1.39)

811

1.29 (1.06,1.58)

 Restricted to women with data for all MD assessment/type of image approachesb

814

1.30 (1.07,1.58)

814

1.47 (1.21,1.78)

814

1.47 (1.22,1.78)

862

1.18 (1.00,1.39)

862

1.32 (1.08,1.61)

Dense area (in cm2)

 All readingsb

952

1.34 (1.15,1.56)

863

1.53 (1.30,1.79)

951

1.45 (1.24,1.68)

952

1.10 (0.96,1.27)

863

1.39 (1.17,1.64)

 Multiple imputationb,c

1098

1.47 (1.38,1.58)

998

1.73 (1.61,1.87)

1097

1.65 (1.54,1.77)

1098

0.99 (0.92,1.06)

998

1.56 (1.42,1.71)

 Restricted to women aged <80 yearsb

899

1.33 (1.14,1.55)

811

1.52 (1.30,1.78)

898

1.46 (1.26,1.70)

899

1.11 (0.97,1.28)

811

1.36 (1.14,1.61)

 Restricted to women with MD data for all MD assessment/type of image approachesb

814

1.30 (1.10,1.54)

814

1.46 (1.24,1.73)

814

1.43 (1.21,1.68)

862

1.11 (0.96,1.28)

862

1.38 (1.17,1.64)

Non-dense area (in cm2)

 All readingsb

952

0.75 (0.61,0.91)

863

0.75 (0.61,0.93)

951

0.65 (0.53,0.79)

952

0.83 (0.67,1.02)

863

0.84 (0.67,1.05)

 Multiple imputationb,c

1098

0.57 (0.52,0.61)

998

0.49 (0.45,0.54)

1097

0.45 (0.41,0.49)

1098

0.61 (0.56,0.68)

998

0.54 (0.49,0.60)

 Restricted to women aged <80 yearsb

899

0.75 (0.61,0.91)

811

0.74 (0.60,0.92)

898

0.64 (0.52,0.78)

899

0.82 (0.66,1.01)

811

0.84 (0.67,1.06)

 Restricted to women with MD data for all MD assessment/type of image approachesb

814

0.78 (0.63,0.98)

814

0.78 (0.62,0.98)

814

0.70 (0.56,0.88)

862

0.82 (0.66,1.01)

862

0.84 (0.67,1.05)

  1. aOdds ratios (OR) represent the change in breast cancer risk associated with one standard deviation (SD) increase in percent density, absolute density and absolute non-density associated with each one of the mammographic density (MD) assessment method/type of image combination. OR and 95 % CI estimated by logistic regression models based on standardised values of square root transformed density measurements (adjusted for age, body mass index, menopausal status, parity, age at menarche, ever-use of oral contraceptive and hormonal therapy). bBased on density measurements taken from the unaffected breast in patients (cases) and a randomly selected breast (left or right) in controls. cMultiple imputation methods used to impute values for women with missing information on age, body mass index, menopausal status and/or parity
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