Outcomes of contralateral prophylactic mastectomy in relation to familial history: a decision analysis (BRCR-D-16-00033)

Table 4 Expected Incidence of Contralateral Breast Cancer (CBC) by Degree of Family History of Breast Cancer

Patient and Disease Characteristics			No. of CBCs/1000 women over 10 years
			No Family History			Breast Cancer in a Second-Degree Relative			Breast Cancer in a First-Degree Relative
			No Family History			Breast Cancer in a Second-Degree Relative			Unilateral			Bilateral
Age (years)	ER Status	Stage	No CPM	CPM	Δ	No CPM	CPM	Δ	No CPM	CPM	Δ	No CPM	CPM	Δ
40	Positive	I	46	2	44	59	3	56	86	4	82	158	9	149
40	Negative	I	58	3	55	74	4	70	108	6	102	193	10	183
40	Positive	II	41	2	39	52	3	49	77	4	73	137	8	129
40	Negative	II	49	2	47	64	3	61	93	5	88	169	9	160
40	Positive	III	29	2	27	36	2	34	54	3	51	98	5	93
40	Negative	III	36	2	34	46	2	44	67	3	64	121	7	114
50	Positive	I	46	2	44	59	3	56	86	5	81	154	8	146
50	Negative	I	57	3	54	73	4	69	107	6	101	191	11	180
50	Positive	II	40	2	38	51	2	49	75	3	72	134	7	127
50	Negative	II	49	2	47	63	3	60	92	5	87	166	9	157
50	Positive	III	28	1	27	36	2	34	53	3	50	95	5	90
50	Negative	III	35	2	33	45	2	43	66	3	63	119	6	113
60	Positive	I	45	2	43	57	3	54	83	4	79	152	8	144
60	Negative	I	54	3	51	70	4	66	102	5	97	183	10	173
60	Positive	II	38	2	36	49	2	47	72	4	68	132	7	125
60	Negative	II	49	3	46	62	3	59	90	5	85	163	9	154
60	Positive	III	28	1	27	36	2	34	53	3	50	95	5	90
60	Negative	III	35	2	33	45	2	43	66	3	63	117	6	111
70	Positive	I	41	2	39	53	3	50	77	4	73	141	8	133
70	Negative	I	52	3	49	66	3	63	96	5	91	173	9	164
70	Positive	II	36	2	34	47	3	44	68	4	64	121	7	114
70	Negative	II	45	2	43	57	3	54	83	4	79	150	8	142
70	Positive	III	26	1	25	34	1	33	50	2	48	89	4	85
70	Negative	III	32	2	30	41	2	39	59	3	56	108	6	102

ER estrogen receptor, CPM contralateral prophylactic mastectomy, Δ, difference (No CPM-CPM); CBC risk reduction = 95% (base-case)

ISSN: 1465-542X