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Table 1 Selected risk factors at time of mammography by case-control status and menopausal status at the time of the mammogram (NHS/NHSII)

From: Mammographic density and breast cancer risk: a mediation analysis

 

Premenopausal

Postmenopausal

 

Cases

N = 559

Controls

N = 1727

Cases

N = 731

Controls

N = 1695

Mean (SD)

 Agea

46.2 (4.6)

46.1 (4.3)

60.1 (7.0)

59.6 (7.4)

 Current BMI (kg/m2)

25.2 (4.8)

25.4 (5.1)

25.9 (4.6)

26.1 (5.0)

 Childhood somatotype

2.5 (1.2)

2.6 (1.2)

2.2 (1.2)

2.4 (1.3)

 Adolescent somatotype

2.8 (1.0)

2.9 (1.1)

2.5 (1.1)

2.7 (1.2)

 BMI at age 18 (kg/m2)

20.8 (2.5)

21.1 (2.7)

20.9 (2.4)

21.1 (2.7)

 Weight change since 18 (lbs)

26.7 (25.8)

26.3 (25.7)

29.7 (25.4)

29.7 (26.8)

 Age at menarche

12.3 (1.4)

12.4 (1.4)

12.5 (1.4)

12.6 (1.4)

 Parity (among parous)

2.4 (1.0)

2.5 (1.0)

3.2 (1.5)

3.2 (1.5)

 Age at first birth (among parous)

26.3 (4.4)

25.9 (4.1)

25.6 (3.7)

25.2 (3.5)

 Breastfeeding (months)

 (among parous women who ever breastfed)

16.3 (10.6)

17.1 (11.1)

12.6 (10.8)

11.4 (9.5)

 Birth index

46.0 (26.4)

46.7 (25.9)

56.4 (37.4)

55.8 (37.7)

 Height (inches)

65.1 (2.6)

64.9 (2.5)

64.5 (2.3)

64.6 (2.4)

 Alcohol use (g/day)

4.2 (6.9)

4.2 (6.3)

5.0 (7.5)

4.8 (7.8)

 Age at menopause (y)

  

47.8 (5.8)

46.7 (6.5)

 Percent density

46.1 (18.7)

39.7 (19.0)

29.2 (17.6)

24.8 (17.2)

 Dense area (cm2)

96.8 (57.5)

81.3 (50.8)

50.7 (38.4)

47.1 (38.9)

 Non-dense area (cm2)

121.4 (77.0)

134.4 (80.4)

141.3 (90.3)

157.5 (91.1)

N (percent)

 Nulliparous

81 (14.5)

228 (13.2)

65 (8.9)

139 (8.2)

 Ever breastfed (among parous)

361 (76.5)

1136 (76.9)

389 (53.6)

940 (55.8)

 Personal history of BBD

  Confirmed by biopsy

154 (27.5)

287 (16.6)

193 (26.4)

382 (22.5)

  Unconfirmed/unknown

170 (30.4)

566 (32.8)

190 (26.0)

423 (25.0)

 Family history of breast cancer

67 (12.0)

146 (8.5)

132 (18.1)

225 (13.3)

 Hormone therapy usea

  Never

  

191 (26.1)

547 (32.3)

  Current

  

401 (54.9)

789 (46.5)

  Past

  

139 (19.0)

359 (21.2)

  1. Number of individuals missing data on the following variables: breastfeeding (n = 42), birth index (n = 169), alcohol use (n = 275), and age at menopause (n = 17, postmenopausal only)
  2. BMI body mass index, BBD benign breast disease
  3. aMatching factor (matched at blood collection)