Fig. 4

Protein tyrosine kinase C theta isoform (PRKCQ) is preferentially expressed in the triple-negative breast cancer (TNBC) subtype and breast cancer cell lines. PRKCQ transcript levels in triple-negative and hormone-receptor-positive or human epidermal growth factor (Her2)-positive patient tumors in The Cancer Genome Atlas dataset (TCGA) (a) and METABRIC dataset (b) were compared. c PKCθ protein expression in breast cancer cell lines was assessed by western analysis. Expression of PRKCδ, another novel PKC isoform, was also examined. GAPDH glyceraldehyde-3-phosphate dehydrogenase