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Fig. 7 | Breast Cancer Research

Fig. 7

From: WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines

Fig. 7

WNT4 expression is increased in hormone receptor-positive and luminal breast tumors. Source data are described in the Methods section. a Left, p value by Mann-Whitney U test for estrogen receptor (ER)-negative vs ER-positive breast tumors. Right, Categories represent PAM50 molecular subtypes. AdjNor Adjacent normal breast tissue. p Values by Tukey’s test for pairwise comparisons; n.s. Not significant (p > 0.05). b and (c) p Values by Mann-Whitney U tests for invasive ductal carcinoma (IDC) vs invasive lobular carcinoma (ILC) in each subset of breast tumors. d WNT4 expression groups were determined on the basis of median expression for all ER-positive breast tumors. p Value represents uncorrected log-rank test for low vs high WNT4 expression. METABRIC Molecular Taxonomy of Breast Cancer International Consortium, TCGA The Cancer Genome Atlas

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