Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis

Breast Cancer Research

Table 4 Logistic regression estimates for the association between microvessel density (MVD) and breast biopsy diagnosis

Breast biopsy diagnosis	N	OR (95 % CI)^a	P
Non-case	174	1.00	0.005
Case	44	1.69 (1.17–2.44)
Non-case	174	1.00	0.002
In situ carcinoma	36	1.36 (0.91–2.04)
Invasive	8	4.86 (1.91–12.38)
Benign	50	1.00	0.002
Proliferative	99	1.56 (1.04–2.33)
Proliferative with atypia	25	1.47 (0.84–2.58)
In situ carcinoma	36	1.89 (1.13–3.15)
Invasive	8	6.81 (2.52–18.42)
Ordinal odds ratio		1.66 (1.27–2.16)	0.002

The average of MVD within a woman was computed and standardized by one standard deviation. Non-cases: non-proliferative benign breast disease, proliferative (ductal hyperplasia; sclerosing adenosis), proliferative with atypia (atypical ductal or lobular hyperplasia). Cases: ductal or lobular carcinoma in situ and invasive cancer
^aAdjusted for age at biopsy (39–44, 45–49, 50–54, 55–59, 60–65 years) and BMI (<25, 25– < 30, 30+ kg/m²)

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