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Table 3 Age- and body mass index (BMI)-adjusted linear regression results for the association between microvessel density (MVD) and mammographic density (MD) measures, overall and by case status

From: Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis

 

All women

Non-cases

Cases

 

N = 218

n = 174

n = 44

MD measure

βa

p

βa

p

βa

p

P heterogeneityb

Global

       

 % density (volume)

0.0004

0.35

0.0003

0.49

0.0005

0.70

0.67

 Dense volume (cm3)

-0.0001

0.11

-0.0003

0.008

-0.00004

0.84

0.43

 Non-dense volume (cm3)

-0.00007

0.04

-0.00008

0.01

0.00001

0.89

0.31

Lesional

       

 % dense volume (cm3)

0.0005

0.16

0.0006

0.16

0.0001

0.93

0.83

 Dense volume (cm3)

0.004

0.08

0.002

0.37

0.01

0.15

0.22

 Non-dense volume (cm3)

0.004

0.03

0.0003

0.90

0.006

0.04

0.09

  1. Beta coefficients with P values < 0.05 are presented in bold font. Non-cases: non-proliferative benign breast disease, proliferative (ductal hyperplasia; sclerosing adenosis), proliferative with atypia (atypical ductal or lobular hyperplasia). Cases: ductal or lobular carcinoma in situ and invasive cancer
  2. aBased on linear regression with the Box-Cox-transformed, standardized average MVD (within a woman) as the outcome and adjusted for age at biopsy (39–44, 45–49, 50–54, 55–59, 60–65 years) and BMI (<25, 25– < 30, 30+ kg/m2)
  3. b P heterogeneity based on a Wald test in the regression model corresponding to an interaction term between case status and the corresponding MD measure
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Breast Cancer Research

ISSN: 1465-542X

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