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Fig. 1 | Breast Cancer Research

Fig. 1

From: Tumor-associated stromal cells as key contributors to the tumor microenvironment

Fig. 1

Tumor-associated stromal cells arise from distinct cellular sources. Tumor-associated stromal cells (TASC) have been found to arise from at least six distinct cellular origins: fibroblasts, pericytes, bone marrow MSCs, adipocytes, endothelial cells that have undergone an endothelial mesenchymal transition (EndMT), or tumor cells that have undergone a epithelial to mesenchymal transition (EMT). Transition of these cells occurs via soluble factors (SF), microRNAs (miR), exosomes (Exo), EMT, or EndMT and results in the formation of the TASC subtypes: tumor-associated fibroblasts (TAF), cancer-associated adipocytes (CAA), or cancer-associated endothelial cells (CAEC)

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