Table 5 A summary of genes significantly downregulated in samples of BRCA1 mutation carriers compared to non-carriers (Benjamini-Hochberg false discovery rate < 0.05 using the t-test)
Gene | Gene name | P value |
|---|---|---|
CSK | c-Src tyrosine kinase | 0.000 |
NRAS | Neuroblastoma RAS viral (v-ras) oncogene homolog | 0.000 |
TGFBR2 | Transforming growth factor, beta receptor II | 0.001 |
XPC | Xeroderma pigmentosum, complementation group C | 0.001 |
BRCA1 | Breast cancer 1, early onset | 0.002 |
PCTK1/CDK16 | Cyclin-dependent kinase 16 | 0.008 |
TOP1 | Topoisomerase (DNA) I | 0.008 |
TNFSF10 | Tumor necrosis factor (ligand) superfamily, member 10 | 0.009 |