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Table 3 The mutation status is the most significant contributor to reduced BRCA1 mRNA levels after adjusting for parity, breastfeeding, and menopause

From: Reduced BRCA1 transcript levels in freshly isolated blood leukocytes from BRCA1 mutation carriers is mutation specific

Model B Coefficient (95 % CI) P value
Constant 179 (128.4, 207.5) <0.001
Mutation status −22.5 (−43.3, −1.7) 0.04
Pregnancy 3.5 (−28, 35) 0.80
Breastfeeding −9.3 (−24, 5.6) 0.20
Menopause −3.5 (−28, 20) 0.70
  1. The model of best-fit incorporated factors significantly contributing to reduced BRCA1 expression levels by linear regression. Covariates were selected based on univariate analyses showing statistically significant correlations with BRCA1 mRNA levels. The mutation status remains the most significant contributor to lower BRCA1 mRNA levels after adjusting for parity, breastfeeding, and menopause (P = 0.04). P value denotes the contribution of each covariate to the linear regression model