Reduced BRCA1 transcript levels in freshly isolated blood leukocytes from BRCA1 mutation carriers is mutation specific

Table 2 Correlation between reproductive or lifestyle factors and BRCA1 mRNA expression

Variable	Unstandardized B (95 % CI)	P value
Age	−0.63 (−1.3, 0.07)	0.08
Parity (ever)	−22.3 (−40, −4.8)	0.01
Breastfeeding (ever)	−12 (−22, −3)	0.009
Age at menarche	−3.7 (−10.2, 2.8)	0.30
Menopause	−23.3 (−43, −4)	0.02
Current oral contraceptive use	−2.5 (−33, 30)	0.90
Current smoking status	−9.3 (−45, 26)	0.60
Current alcohol consumption	0.115 (−28, 28)	1.00
Mastectomy	−15.3 (−41, 10)	0.23
Oophorectomy	−24 (−45, −3.4)	0.02
Current hormone replacement therapy use	0.5 (−11.8, 12.8)	0.93
Body mass index	0.445 (−1.5, 2.3)	0.65
Mutation status	−28.5 (−46, −11)	0.002

Data are provided as linear regression coefficient, Unstandardized B coefficient and 95 % confidence intervals. P value < 0.05 denotes statistical significance

ISSN: 1465-542X