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Fig. 9 | Breast Cancer Research

Fig. 9

From: SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway

Fig. 9

PTK2 activation is essential for SMARCE1-mediated anoikis resistance in breast cancer cells. a Expression levels of PTK2 mRNA in LM derivatives. b PTK2 protein expression and phosphorylation in LM derivatives cultured in polyHEMA-coated dishes. c Effect on PTK2 overexpression on viability of LM derivatives cultured in polyHEMA-coated dishes. d Effect on PTK2 overexpression on caspase activation in LM derivatives cultured in polyHEMA-coated dishes. Caspase activity was normalized to cell numbers and results from three independent experiments were presented as means ± SE. e Expression levels of PTK2 mRNA in BT549 derivative. f Effect of PTK2 knockdown on viability of BT549 derivative cultured in polyHEMA-coated dishes. *p < 0.05, Student t test. EV empty vector, KD knockdown, LM lung metastatic cell line derived from MDA-MB-231

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