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Fig. 5 | Breast Cancer Research

Fig. 5

From: SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway

Fig. 5

SMARCE1-dependent activation of PTK2, ERK, and AKT pathways by cell detachment. a Effect of SMARCE1 knockdown in LM cells on detachment-induced activation of pro-survival (FAK/PTK2, ERK, and AKT) and pro-apoptotic (BIM) signaling pathways. b Effect of SMARCE1 knockdown in HCC38 cells. c Effect of SMARCE1 overexpression in BT549 cells. The levels of protein expression and phosphorylation were determined by immunoblotting assays. GAPDH was included as a loading control. EV empty vector, KD knockdown, LM lung metastatic cell line derived from MDA-MB-231

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