Fig. 10
From: SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway
Blocking SMARCE1 expression sensitizes non-tumorigenic mammary epithelial cells to anoikis. a Effect of SMARCE1 knockdown by stable shRNA expression on viability of 184B5 cells cultured in polyHEMA-coated dishes. b Effect of stable shRNA expression (SMARCE1-KD) and SMARCE1-siRNA delivery (SMARCE1-i) on caspase activation in 184B5 cells cultured in polyHEMA-coated dishes. Caspase activity was measured by using the Caspase-Glo 3/7 assay kit and normalized to cell numbers. The results from three independent experiments were presented as means ± SE. c Detachment-induced PTK2 mRNA expression is abolished by SMARCE1-KD or SMARCE1-i in 184B5 cells. mRNA levels were measured by qPCR. EV empty vector, KD knockdown