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Fig. 2 | Breast Cancer Research

Fig. 2

From: Quantitative assessment of the spatial heterogeneity of tumor-infiltrating lymphocytes in breast cancer

Fig. 2

Distribution of AQUA® QIF scores of CD3 (T cells, a), CD8 (cytotoxic T cells, b), and CD20 (B lymphocytes, c) markers across three cores from 31 individual breast tumors. The 33 patient cases were randomly distributed into three staining batches completed on consecutive days where all three biopsies per tumor were stained within the same batch. The three core biopsy sets from each tumor are grouped together sequentially and are represented by the same color. Each tumor (three biopsy set) is color-coded with alternating red and blue dots for visual clarity between patients. Each dot represents a QIF score from a single field of view (FOV) from each biopsy. QIF scores are expressed as arbitrary units of fluorescence (AU) using the AQUA® algorithm. The mean score and standard error of the mean (SEM) for each core are indicated with a black dot/bar, respectively

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