Fig. 5

MicroRNA (MiRNA) gene targets and hallmarks of cancer. Enriched functional and pathway terms were combined according to the hallmarks of cancer [38]. The heatmap indicates the number of miRNA-regulated genes annotated to each hallmark at each time point. An additional category, 'Neural genetics', was added to combine biological terms related to neural processes and disorders. Red indicates high transcriptional activity for the corresponding hallmark and time point. The heatmap suggests that activation invasion and metastasis, sustaining proliferative signaling, and evading growth suppressors are more active, especially in the transition to the carcinoma stages