Patient/imaging characteristics | Cancer cases (n = 51) | Controls (n = 51) | |
---|---|---|---|
Diagnostic BI-RADS findings in single-side breast on mammography and/or ultrasound | |||
 Breast with lesion (cancer/benign) | BI-RADS 4 | 11 (22 %) | 47 (92 %) |
BI-RADS 5 | 40 (78 %) | 4 (8 %) | |
 Contralateral (studied) breast | BI-RADS 1 | 27 (53 %) | 21 (41 %) |
BI-RADS 2 | 19 (37 %) | 25 (49 %) | |
BI-RADS 3 | 1 (2 %) | 1 (2 %) | |
BI-RADS 4 | 4 (8 %) | 4 (8 %) | |
BI-RADS 5 | 0 (0 %) | 0 (0 %) | |
Age, years, mean ± SD (range) | 47.6 ± 7.4 (34–60) | 47.1 ± 7.3 (31–60) | |
Menopausal status | |||
 Premenopausal | 28 (55 %) | 30 (59 %) | |
 Postmenopausal | 23 (45 %) | 21 (41 %) | |
Known pathogenic BRCA1/2 mutation | 2 (4 %) | 0 (0 %) | |
History of prior breast cancer | 0 (0 %) | 0 (0 %) | |
Family history of breast cancer | 26 (51 %) | 31 (61 %) | |
Family history of ovarian cancer | 3 (6 %) | 0 (0 %) | |
Prior biopsy (>1Â year prior to the studied biopsy) | |||
 Atypia | 1 (2 %) | 0 (0 %) | |
 Benign abnormality | 9 (18 %) | 6 (12 %) | |
Exogenous hormone use | |||
 Hormone replacement therapy | 7 (14 %) | 5 (10 %) | |
 Birth control pills | 33 (65 %) | 34 (67 %) | |
 Tamoxifen | 1 (2 %) | 0 (0 %) | |
 None | 5 (10 %) | 12 (24 %) | |
 Oophorectomy | 0 (0 %) | 0 (0 %) | |
Mammographic density (visual BI-RADS density description) | |||
 Fatty | 2 (4 %) | 1 (2 %) | |
 Scattered fibroglandular density | 14 (27 %) | 13 (25 %) | |
 Heterogeneously dense | 32 (63 %) | 33 (65 %) | |
 Extremely dense | 3 (6 %) | 4 (8 %) | |
Background parenchymal enhancement, BPE%, mean ± SD (range) | 44.6 ± 8.9 (20.9–62.0) | 39.8 ± 11.4 (17.9–61.6) | |
Kinetics imaging measures, mean ± SD (range) | |||
Wash-in slope variance × 100 (unit) | 2.90 ± 2.72 (0.48–15.42) | 1.75 ± 1.26 (0.43–6.87) | |
Signal enhancement ratio volume, cm3 | 118.9 ± 85.6 (26.1–429.8) | 80.4 ± 42.9 (21.1–194.5) |