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Table 1 Patient and imaging characteristics of the 102 patients including 51 breast cancer cases and 51 matched controls with biopsy-proven benign lesions

From: Breast MRI contrast enhancement kinetics of normal parenchyma correlate with presence of breast cancer

Patient/imaging characteristics

Cancer cases (n = 51)

Controls (n = 51)

Diagnostic BI-RADS findings in single-side breast on mammography and/or ultrasound

 Breast with lesion (cancer/benign)

BI-RADS 4

11 (22 %)

47 (92 %)

BI-RADS 5

40 (78 %)

4 (8 %)

 Contralateral (studied) breast

BI-RADS 1

27 (53 %)

21 (41 %)

BI-RADS 2

19 (37 %)

25 (49 %)

BI-RADS 3

1 (2 %)

1 (2 %)

BI-RADS 4

4 (8 %)

4 (8 %)

BI-RADS 5

0 (0 %)

0 (0 %)

Age, years, mean ± SD (range)

47.6 ± 7.4 (34–60)

47.1 ± 7.3 (31–60)

Menopausal status

 Premenopausal

28 (55 %)

30 (59 %)

 Postmenopausal

23 (45 %)

21 (41 %)

Known pathogenic BRCA1/2 mutation

2 (4 %)

0 (0 %)

History of prior breast cancer

0 (0 %)

0 (0 %)

Family history of breast cancer

26 (51 %)

31 (61 %)

Family history of ovarian cancer

3 (6 %)

0 (0 %)

Prior biopsy (>1 year prior to the studied biopsy)

 Atypia

1 (2 %)

0 (0 %)

 Benign abnormality

9 (18 %)

6 (12 %)

Exogenous hormone use

 Hormone replacement therapy

7 (14 %)

5 (10 %)

 Birth control pills

33 (65 %)

34 (67 %)

 Tamoxifen

1 (2 %)

0 (0 %)

 None

5 (10 %)

12 (24 %)

 Oophorectomy

0 (0 %)

0 (0 %)

Mammographic density (visual BI-RADS density description)

 Fatty

2 (4 %)

1 (2 %)

 Scattered fibroglandular density

14 (27 %)

13 (25 %)

 Heterogeneously dense

32 (63 %)

33 (65 %)

 Extremely dense

3 (6 %)

4 (8 %)

Background parenchymal enhancement, BPE%, mean ± SD (range)

44.6 ± 8.9 (20.9–62.0)

39.8 ± 11.4 (17.9–61.6)

Kinetics imaging measures, mean ± SD (range)

Wash-in slope variance × 100 (unit)

2.90 ± 2.72 (0.48–15.42)

1.75 ± 1.26 (0.43–6.87)

Signal enhancement ratio volume, cm3

118.9 ± 85.6 (26.1–429.8)

80.4 ± 42.9 (21.1–194.5)

  1. Data are numbers of subjects, with percentages in parentheses, unless stated otherwise. BI-RADS Breast Imaging-Reporting and Data System