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Fig. 4 | Breast Cancer Research

Fig. 4

From: Paternal programming of breast cancer risk in daughters in a rat model: opposing effects of animal- and plant-based high-fat diets

Fig. 4

Quantification of cell proliferation and apoptosis in mammary gland and tumors. a Photomicrograph (×20 original magnification) of Ki-67 immunostaining (cells indicated by arrows). b Quantification of cell proliferation in the mammary gland ducts and lobules of 50-day-old female offspring of control diet (CO)-, lard (LB)-, and corn oil (CB)-fed male rats. c Quantification of cell proliferation in mammary tumors of female offspring from CO-, LB-, and CB-fed male rats. d Photomicrograph (×40 original magnification) showing apoptotic cells (indicated by arrows). e Quantification of apoptosis in the mammary gland ducts and lobules of 50-day-old female offspring of CO-, LB-, and CB-fed male rats. f Quantification of apoptosis in mammary tumors of female offspring of CO-, LB-, and CB-fed males. Statistically significant difference (p ≤ 0.05) compared with aCO and bLB, according to analysis of variance followed by a least significant difference test. Marginal difference (p ≤ 0.06) compared with cCO and dLB, according to t test. The data are expressed as mean ± SEM (n = 4 per group)

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