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Fig. 6 | Breast Cancer Research

Fig. 6

From: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

Fig. 6

Small interfering RNA (siRNA) knockdown of mitotic network genes in the breast cancer cell line MDAMB231. Cells were transiently transfected with siRNAs targeting mitotic apparatus genes and cell viability, and mRNA levels were assayed. a Cell viability was measured after 72 hours and normalized to non-specific siRNA, which served as a negative control. siRNAs that induced significant growth inhibition (p < 0.05) relative to a control siRNA based on the two-tailed Student’s t test are indicated. b mRNA levels were quantified after siRNA knockdown by normalizing to mRNA levels after treatment with a control siRNA

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Breast Cancer Research

ISSN: 1465-542X

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