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Fig. 2 | Breast Cancer Research

Fig. 2

From: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

Fig. 2

Mitotic network activity is elevated in a subset of breast cancers. Mitotic network activity index (MNAI) defined as the sum of the expression levels of the 54 mitotic network genes. Heatmaps illustrate mitotic network gene expression in breast cell lines (n = 53) [23] (basal vs. luminal subtype), p < 0.0001 (a), primary breast tumors from dataset 1 (n = 101) p < 0.001 (b), and primary tumors in the dataset from Curtis dataset. (n = 1980), p < 0.00001 (c), between basal and luminal tumors (PAM50) and integrated cluster 10 (IC10) vs. other subgroups (ICs) based on analysis of variance. LumA luminal A, LumB luminal B, Her2 human epidermal growth factor receptor 2, ER estrogen receptor

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Breast Cancer Research

ISSN: 1465-542X

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