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Table 1 Characteristics of breast cancer patients in the WECARE I and II Study

From: Systemic therapy for breast cancer and risk of subsequent contralateral breast cancer in the WECARE Study

Characteristics

CBC cases

UBC controls

N (%)

N (%)

Overall numbers

1521 (100)

2212 (100)

Study area

  

 Iowaa

201(13)

314 (14)

 Seattleb

224 (15)

317 (14)

 Ontarioc

159 (10)

157 (7)

 Californiad

658 (43)

967 (44)

 Denmarke

279 (18)

457 (21)

Age at first breast cancer (years)

  

 ≤39

268 (18)

384 (17)

 40–49

808 (53)

1180 (53)

 50–54

445 (29)

648 (29)

Age at CBC/reference date (years)

  

 ≤39

100 (6)

147 (7)

 40–49

446 (29)

691 (31)

 50–59

719 (48)

1087 (49)

 ≥60

256 (17)

287 (13)

Year of diagnosis of first breast cancer

  

 1985–1989

303 (20)

580 (26)

 1990–1994

572 (38)

871 (39)

 1995–1999

426 (28)

551 (25)

 2000–2004

186 (12)

190 (9)

 2005–2008

34 (2)

20 (1)

Time since first breast cancer (years)

  

 1–4

586 (39)

986 (45)

 5–9

574 (38)

804 (36)

 ≥10

361 (24)

422 (19)

First-degree family history of breast cancer

  

 Yes

497 (33)

466 (21)

 No

1004 (66)

1706 (77)

 Unknown

20 (1)

40 (2)

Lobular histology of first breast cancer

  

 Yes

179 (12)

223 (10)

 No

1342 (88)

1989 (90)

Stage of first breast cancer

  

 Local

1061 (70)

1442 (65)

 Regional

448 (29)

759 (34)

 Unknown

12 (1)

11 (1)

ER/PR status of the first breast cancer

  

 Positive

863 (57)

1379 (62)

 Negative

413 (27)

473 (21)

 Unknown

245 (16)

360 (16)

Radiation for first breast cancerf

  

 Yes

880 (58)

1686 (76)

 No

641 (42)

525 (24)

Chemotherapy for first breast cancer

  

 Yes

822 (54)

1289 (58)

 No

699 (46)

923 (42)

Tamoxifen use for first breast cancer

  

 Yes

467 (31)

787 (36)

 No

1054 (69)

1425 (64)

Other endocrine therapy for first breast cancerg

  

 Yes

89 (6)

141 (6)

 No

1432 (94)

2071 (94)

  1. aThe State Health Registry of Iowa
  2. bCancer Surveillance System of the Fred Hutchinson Cancer Research Center
  3. cThe Ontario Cancer Registry
  4. dFour study centers: 1) Los Angeles County Cancer Surveillance Program, 2) The Cancer Surveillance Program of Orange County/San Diego-Imperial Organization for Cancer Control, 3) Greater Bay Area Cancer Registry (San Francisco Bay Area Region and Santa Clara Region), and 4) Sacramento and Sierra Center Registry (Sacramento Region)
  5. eThe Danish Breast Cancer Cooperative Group Database supplemented by the Danish Cancer Registry
  6. fRadiation for first breast cancer was unknown for one control
  7. gAromatase inhibitors (67 cases and 99 controls) and other anti-estrogens
  8. CBC contralateral breast cancer, ER/PR estrogen receptor/progesterone receptor (if either ER or PR was positive, we considered the ER/PR status as positive), UBC unilateral breast cancer