Table 1 Tumor sampling characteristics of cases with estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 discordance between tissue microarray cores in phase III of the Carolina Breast Cancer Study
From: Intratumoral heterogeneity as a source of discordance in breast cancer biomarker classification
| Â | ER | PR | HER2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  | n (%) | Conc (n = 985) | Disc (n = 100) | p Value | n (%) | Conc (n = 916) | Disc (n = 169) | p Value | n (%) | Conc (n = 889) | Disc (n = 196) | p Value |
Cellularity, median (IQR) | 1085 (100) | 5225 (2846–8869) | 3564 (2142–6074) | <0.001 | 1085 (100) | 5772 (3018–9851) | 3785 (2238–7925) | <0.001 | 1,085 (100) | 7303 (4134–11,329) | 8233 (4414–12,675) | 0.282 |
Core number | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 2 | 113 (10) | 102 (90) | 11 (10) | 0.978 | 113 (10) | 111 (98) | 10 (9) | 0.098 | 106 (10) | 87 (82) | 19 (18) | 0.043 |
 3 | 287 (26) | 261 (91) | 26 (9) | 299 (28) | 253 (85) | 46 (15) | 289 (27) | 223 (77) | 66 (23) | |||
 4 | 685 (63) | 622 (91) | 63 (9) | 673 (61) | 560 (83) | 113 (17) | 690 (64) | 579 (84) | 111 (16) | |||