Fig. 1
From: Intratumoral heterogeneity as a source of discordance in breast cancer biomarker classification
ER, PR, and HER2 expression in cases with discordant biomarker status between cores, restricted to positive (≥1 %) cases for ER and PR and to cases with at least one 3+ core (≥10 % 3+) for HER2. Individual cases are ordered on the x-axis by case-level biomarker expression level (smaller solid circles: red = negative, blue = borderline/equivocal, green = positive). Individual cores for each case are represented by solid black circles for cases with manually confirmed heterogeneity or by X’s for cases without manually confirmed heterogeneity. ER estrogen receptor, HER2 human epidermal growth receptor 2, PR progesterone receptor