Fig. 3

Unsupervised analysis of luminal-A (LumA) breast samples. a Clustering of 534 RNA-Seq profiles partitions the data into two groups exhibiting distinct expression profiles. The clusters also show significant enrichment for clinical variables including recurrence, proliferation score, age, and histology. The bars below the heatmap show, from top to bottom, the partition of the samples, the designation of the samples according to the clustering of all luminal samples (see Fig. 2), histological type, and proliferation scores. b Five-year survival and recurrence analysis in the two luminal-A subgroups. LumA-R2 samples exhibit significantly reduced five-year recurrence rate compared with LumA-R1