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Table 6 Adjusted hazard ratios for the associations between changes in strenuous recreational physical activity levels and invasive breast cancer

From: Recreational physical activity and risk of triple negative breast cancer in the California Teachers Study

RPA at baselinea, h/wk/y RPA at 10-year follow-upb, h/wk/y Overall Observed person-years Cases, no. Adjusted HR (95 % CI)
Breast cancer overall
 No change
  Low (≤0.50) Low (≤0.50) 24,028 396,185 692 Referent
  Intermediate (0.51–3.50) Intermediate (0.51–3.50) 6273 104,479 155 1.01 (0.84–1.21)
  High (≥3.51) High (≥3.51) 2462 41,105 42 0.71 (0.52–0.98)
 Increasing
  Low (≤0.50) Intermediate (0.51–3.50) 5640 93,840 127 0.86 (0.71–1.04)
  Low (≤0.50) High (≥3.51) 1267 21,076 34 1.03 (0.72–1.45)
  Intermediate (0.51–3.50) High (≥3.51) 1751 29,121 40 0.89 (0.64–1.23)
 Decreasing
  Intermediate (0.51–3.50) Low (≤0.50) 8436 139,718 209 0.96 (0.82–1.12)
  High (≥3.51) Low (≤0.50) 2212 36,515 58 1.00 (0.76–1.32)
  High (≥3.51) Intermediate (0.51–3.50) 2617 43,519 46 0.75 (0.55–1.02)
  1. Results are for 54,686 women who completed baseline and 10-year follow-up questionnaires regarding RPA in recent 3 years in the California Teachers Study, 1995–2012. HRs are from multivariable Cox proportional hazards regression models using age (in days) as the time metric and stratified by age (in years) with the adjustment for race, family history of breast cancer in first-degree relatives, combined age at first full-term pregnancy and parity variable, combined menopausal status and MHT use variable, BMI at baseline, history of smoking, alcohol intake during the past year of baseline, screening mammogram in the past 2 years of baseline, history of a breast biopsy, and a corresponding changes in level of moderate RPA variable
  2. Abbreviations: BMI body mass index, CI confidence interval, HR hazard ratio, h/wk/y hour/week/year, MHT menopausal hormone therapy, RPA recreational physical activity
  3. aRPA during the 3 years prior to baseline
  4. bRPA during the 3 years prior to 10-year follow-up