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Table 4 Risk of interval versus screen-detected cancer according to BMI and mammographic measures

From: Mammographic density and risk of breast cancer by mode of detection and tumor size: a case-control study

   OPERA (95 % CI)
   BMI BMI + DA + NDA BMI + PDA BMI + DA DA + NDA PDA DA
All BIC, AUC 527, 0.60 511, 0.68 508, 0.67 518, 0.65 506, 0.67 504, 0.67 514, 0.64
244 SDC/148 IC BMI per 1 SD 0.89 (0.73, 1.09) 0.88 (0.71, 1.08) 0.88 (0.72, 1.08) 0.88 (0.72, 1.08)    
  DA per adjusted 1 SD   1.46 (1.18, 1.82)   1.52 (1.22, 1.89) 1.46 (1.17, 1.81)   1.51 (1.22, 1.87)
  PDA per adjusted 1 SD    1.76 (1.40,2.23)    1.76 (1.39,2.22)  
  NDA per adjusted 1 SD   0.67 (0.54, 0.83)    0.67 (0.54, 0.84)   
Small tumors BIC, AUC 321, 0.65 319, 0.70 314, 0.70 320, 0.67 318, 0.68 313, 0.68 321, 0.65
192 SDC/76 IC BMI per 1 SD 0.67 (0.49, 0.91) 0.72 (0.53, 0.98) 0.72 (0.52, 0.98) 0.68 (0.50, 0.94)    
  DA per adjusted 1 SD   1.42 (1.05, 1.93)   1.46 (1.08, 1.98) 1.45 (1.08, 1.96)   1.49 (1.10, 2.01)
  PDA per adjusted 1 SD    1.73 (1.25, 2.39)    1.79 (1.30, 2.47)  
  NDA per adjusted 1 SD   0.69 (0.53, 0.91)    0.68 (0.52, 0.89)   
Large tumors BIC, AUC 168, 0.57 168, 0.68 166, 0.66 169, 0.63 164, 0.68 161, 0.66 164, 0.63
49 SDC/65 IC BMI per 1 SD 1.10 (0.78,1.54) 0.98 (0.68, 1.43) 1.01 (0.70, 1.45) 1.04 (0.73, 1.47)    
  DA per adjusted 1 SD   1.44 (0.96, 2.17)   1.48 (1.00, 2.21) 1.44 (0.96, 2.16)   1.49 (1.01, 2.21)
  PDA per adjusted 1 SD    1.81 (1.16, 2.83)    1.81 (1.16, 2.82)  
  NDA per adjusted 1 SD   0.57 (0.35, 0.94)    0.58 (0.35, 0.94)   
  1. All of the estimates from unconditional logistic regression were adjusted for age at mammogram and the variables included into the model. AUC area under the receiver operating characteristic curve, BIC Bayesian information criterion, BMI body mass index, CI confidence interval, DA dense area, IC interval cases, NDA non-dense area, OPERA odds per adjusted standard deviation, PDA percent dense area, SD standard deviation, SDC screen-detected cases