OPERA (95 % CI) | ||||||||
---|---|---|---|---|---|---|---|---|
BMI | BMI + DA + NDA | BMI + PDA | BMI + DA | DA + NDA | PDA | DA | ||
Screen-detected, small tumors | BIC, AUC | 516, 0.64 | 528, 0.65 | 521, 0.65 | 521, 0.65 | 521, 0.62 | 515, 0.62 | 515, 0.62 |
(192 cases/552 controls) | BMI per 1 SD | |||||||
At age 50 years | 0.91 (0.64, 1.31) | 0.92 (0.64, 1.33) | 0.93 (0.65, 1.33) | 0.93 (0.65, 1.33) | ||||
At age 70 years | 1.32 (1.07, 1.62) | 1.32 (1.08, 1.62) | 1.32 (1.07, 1.62) | 1.32 (1.07, 1.62) | ||||
P for interactiona | 0.10 | 0.11 | 0.12 | 0.12 | ||||
DA per adjusted 1 SD | 1.09 (0.93, 1.28) | 1.10 (0.93, 1.29) | 1.08 (0.92, 1.28) | 1.09 (0.93, 1.28) | ||||
PDA per adjusted 1 SD | 1.12 (0.94, 1.32) | 1.11 (0.94, 1.31) | ||||||
NDA per adjusted 1 SD | 0.96 (0.82, 1.13) | 0.97 (0.82, 1.14) | ||||||
Screen-detected, large tumors | BIC, AUC | 145, 0.60 | 147, 0.69 | 142, 0.69 | 142, 0.69 | 136, 0.69 | 132, 0.69 | 132, 0.69 |
(49 cases/141 controls) | BMI per 1 SD | |||||||
At age 50 years | 0.78 (0.32, 1.92) | 0.83 (0.32, 2.14) | 0.83 (0.33, 2.10) | 0.79 (0.30, 2.07) | ||||
At age 70 years | 1.14 (0.71, 1.83) | 1.09 (0.64, 1.84) | 1.10 (0.65, 1.85) | 1.11 (0.66, 1.87) | ||||
P for interactiona | 0.49 | 0.65 | 0.63 | 0.56 | ||||
DA per adjusted 1 SD | 1.56 (1.12, 2.19) | 1.58 (1.12, 2.22) | 1.57 (1.12, 2.20) | 1.59 (1.13, 2.24) | ||||
PDA per adjusted 1 SD | 1.64 (1.13, 2.38) | 1.66 (1.14, 2.40) | ||||||
NDA per adjusted 1 SD | 0.85 (0.58, 1.24) | 0.84 (0.57, 1.22) | ||||||
Interval cases, small tumors | BIC, AUC | 217, 0.62 | 208, 0.74 | 203, 0.74 | 211, 0.70 | 199, 0.73 | 194, 0.73 | 203, 0.69 |
(76 cases/224 controls) | BMI per 1 SD | |||||||
At age 50 years | 0.76 (0.43, 1.32) | 0.68 (0.37, 1.25) | 0.68 (0.37, 1.24) | 0.70 (0.38, 1.26) | ||||
At age 70 years | 0.88 (0.54, 1.43) | 0.96 (0.58, 1.57) | 0.93 (0.57, 1.51) | 0.89 (0.55, 1.46) | ||||
P for interactiona | 0.73 | 0.46 | 0.49 | 0.58 | ||||
DA per adjusted 1 SD | 1.65 (1.22, 2.23) | 1.64 (1.22, 2.21) | 1.61 (1.20, 2.17) | 1.60 (1.20, 2.15) | ||||
PDA per adjusted 1 SD | 1.99 (1.43, 2.77) | 1.94 (1.40, 2.68) | ||||||
NDA per adjusted 1 SD | 0.65 (0.48, 0.86) | 0.65 (0.49, 0.86) | ||||||
Interval cases, large tumors | BIC, AUC | 196, 0.59 | 163, 0.82 | 159, 0.82 | 167, 0.79 | 152, 0.82 | 148, 0.82 | 156, 0.79 |
(65 cases/204 controls) | BMI per 1 SD | |||||||
At age 50 years | 1.23 (0.67, 2.23) | 0.99 (0.52, 1.87) | 0.95 (0.51, 1.78) | 0.99 (0.52, 1.89) | ||||
At age 70 years | 1.11 (0.73, 1.70) | 0.92 (0.54, 1.57) | 0.94 (0.55, 1.60) | 0.94 (0.58, 1.53) | ||||
P for interactiona | 0.83 | 0.89 | 0.98 | 0.91 | ||||
DA per adjusted 1 SD | 2.77 (1.86, 4.14) | 2.73 (1.87, 4.00) | 2.74 (1.85, 4.05) | 2.70 (1.86, 3.92) | ||||
PDA per adjusted 1 SD | 3.49 (2.19, 5.56) | 3.43 (2.18, 5.41) | ||||||
NDA per adjusted 1 SD | 0.58 (0.40, 0.83) | 0.58 (0.40, 0.83) |