SNPs | Position (hg 19) | Alleles | EAF | LD (r 2)§ | Univariate analysis | Conditional analysis | |||
---|---|---|---|---|---|---|---|---|---|
Per-allele effect (95 % CI)a | P-trend | Per-allele effect (95 % CI)b | P-trend | ||||||
Indexǂ | rs10771399 | 28155080 | G*/A | 0.10 | - | 0.86 (0.80–0.91) | 3 × 10-6 | - | - |
Meta-analysis of ER-negative cancer (BCAC + CIMBA) | |||||||||
BCAC ER- | |||||||||
Signal 1 | rs7297051 | 28174817 | T*/C | 0.24 | 0.42 | 0.87 (0.83–0.91) | 3 × 10-10 | 0.89 (0.85–0.94) | 1 × 10-5 |
Signal 4 | rs113824616 | 28184905 | C*/T | 0.05 | 0.40 | 0.75 (0.67–0.84) | 5 × 10-7 | 0.86 (0.76–0.98) | 0.02 |
CIMBA BRCA1 mutation carriers | |||||||||
Signal 1 | rs7297051 | 28174817 | T*/C | 0.23 | 0.37 | 0.89 (0.85–0.93) | 3 × 10-7 | 0.94 (0.90–0.98) | 0.003 |
Signal 4 | rs113824616 | 28184905 | C*/T | 0.04 | 0.49 | 0.73 (0.64–0.82) | 1 × 10-7 | 0.83 (0.74–0.93) | 0.001 |