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Table 2 Associations between common haplotypes derived using lead single nucleotide polymorphisms and breast cancer risk in women of European ancestry

From: Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus

Haplotype

Overall breast cancer

Breast cancer (age at diagnosis <45 years)

Breast cancer (age at diagnosis ≥45 years)

P heterogeneity b

rs805510 - rs7297051- rs1871152

Frequency

OR (95 % CI)a

P value

Frequency

OR (95 % CI)a

P value

Frequency

OR (95 % CI)a

P value

 

C-C-A

0.51

1.00 (Ref)

Ref

0.52

1.00 (Ref)

Ref

0.51

1.00 (Ref)

Ref

-

C-C-G

0.24

0.92 (0.89–0.95)

7 × 10-8

0.22

0.94 (0.89–1.00)

0.04

0.24

0.92 (0.89–0.95)

4 × 10-7

0.24

C-T-A

0.09

0.90 (0.87–0.95)

3 × 10-6

0.09

0.96 (0.89–1.03)

0.28

0.09

0.90 (0.86–0.94)

4 × 10-7

0.09

C-T-G

0.03

0.89 (0.82–0.96)

2 × 10-3

0.03

0.85 (0.73–0.98)

0.02

0.03

0.89 (0.82–0.96)

3 × 10-3

0.37

T-T-A

0.04

0.82 (0.77–0.88)

9 × 10-9

0.04

0.76 (0.67–0.87)

5 × 10-5

0.04

0.83 (0.76–0.85)

5 × 10-8

0.19

T-T-G

0.07

0.79 (0.76–0.83)

3 × 10-23

0.06

0.78 (0.71–0.85)

5 × 10-8

0.07

0.81 (0.77–0.85)

3 × 10-18

0.45

Rare

0.01

0.88 (0.79–0.99)

0.04

0.01

0.90 (0.72–1.13)

0.37

0.01

0.88 (0.78–0.99)

0.04

0.45

  1. aAdjusted for studies and the top principal components. b P for heterogeneity between cases with age at diagnosis <45 years and ≥45 years. Ref reference
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Breast Cancer Research

ISSN: 1465-542X

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