Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation

Table 3 Association between APOBEC3B copy number and clinicopathologic features of breast cancers^a

Clinical variables	Data available N (%)	A3B ^wt/wt	A3B ^del/wt	A3B ^del/del	P value
Age (year)	1451 (100)	50.0 ± 7.4	51.0 ± 7.8	51.0 ± 7.1	0.23^b
Grade 1/2/3 (%)	1140 (78.6)	14/51/36	11/54/36	14/51/36	0.76^c
Size (cm)	1220 (84.1)	2.5 ± 2.5	2.5 ± 2.2	2.5 ± 1.7	0.93^b
Node + (%)	1308 (90.1)	47.7	44.4	39.7	0.17^c
ER+ (%)	1370 (94.4)	65.8	68.7	65.2	0.49^c
PR+ (%)	1346 (92.8)	51.1	51.0	47.5	0.65^c
HER2 (%)	1328 (91.5)	49.0	44.6	40.4	0.09^c
TNBC (%)	1240 (87.7)	12.5	12.2	17.5	0.17^c

A3B ^wt/wt no deletion, A3B ^del/wt one-copy deletion, A3B ^del/del two-copy deletion, ER+ estrogen receptor positive, PR+ progesterone receptor positive, HER2 human epithelial receptor 2, TNBC triple-negative breast cancer
^aUnless otherwise specified, data are presented in median ± interquartile range
^bANOVA
^cChi-squared test

ISSN: 1465-542X