Case-control study of mammographic density and breast cancer risk using processed digital mammograms

Breast Cancer Research

Table 2 Percent density, overall and for women age 50+ at mammogram

Quintile group	Frequency		Model 1^a		Model 2^b		Model 3^c
	Case	Control	OR	95 % CI	OR	95 % CI	OR	95 % CI
Percent density, overall (297 cases and 1149 controls)
Q1: 6.08 or less	40	229	1.00	Ref	1.00	Ref	1.00	Ref
Q2: 6.09–11.94	49	230	1.41	0.87–2.29	1.41	0.86–2.29	1.49	0.91–2.45
Q3: 11.95–20.04	60	230	2.37	1.44–3.89	2.38	1.44–3.91	2.57	1.54–4.30
Q4: 20.05–31.56	69	230	3.08	1.87–5.06	2.95	1.79–4.88	3.22	1.91–5.43
Q5: 31.57+	79	230	4.45	2.62–7.56	4.36	2.55–7.43	4.88	2.78–8.55
Percent density^d			1.66	1.39–1.97	1.64	1.38–1.96	1.70	1.41–2.04
Percent density, women age 50+ (288 cases and 1116 controls)
Q1: 6.07 or less	40	223	1.00	Ref	1.00	Ref	1.00	Ref
Q2: 6.08–11.71	48	223	1.39	0.85–2.26	1.39	0.85–2.27	1.47	0.89–2.43
Q3: 11.72–19.71	57	223	2.23	1.35–3.68	2.24	1.36–3.71	2.43	1.45–4.08
Q4: 19.72-30.97	66	223	2.97	1.79–4.92	2.87	1.72–4.76	3.13	1.85–5.31
Q5: 30.98+	77	224	4.22	2.49–7.16	4.16	2.45–7.08	4.65	2.66–8.14
Percent density^d			1.64	1.38–1.95	1.63	1.36–1.94	1.68	1.40–2.02

^aAdjusted for matching factors (age at FFDM, laterality, density batch number), BMI (continuous), and BMI (categorical)
^bAdjusted for matching factors, BMI (categorical and continuous), parity, first-degree family history, and hormone use
^cAdjusted for matching factors, BMI (categorical and continuous), parity, first-degree family history, hormone use, and breast area (continuous)
^dORs for square root of percent density (continuous) per standard deviation unit

ISSN: 1465-542X