Table 2 Changes in lipids and small molecule metabolites from serum liquid chromatography mass spectrometry-positive (LCMS+) mode with intermittent energy restriction (n = 23 women)

Glycerolipid (DG)

Major constituent of adipose tissue

12

4 Down

0 Down

0 Down

1 Up

7 Up

8 Up

7 NS

5 NS

4 NS

Fatty acid lipid (FA)

Complex lipid building block

30

23 Down

0 Down

0 Down

2 Up

2 Up

25 Up

5 NS

28 NS

5 NS

Cholesterol-based

Steroid precursor/cell membrane integrity

7

6 Down

0 Down

0 Down

0 Up

0 Up

7 Up

1 NS

7 NS

0 NS

Phosphatylcholine lipid (PC)

Major structure lipid in cell membranes

52

37 Down

1 Down

6 Down

10 Up

2 Up

36 Up

5 NS

49 NS

10 NS

Phosphatidylethanolamine lipid (PE)

Role in the release of lipoproteins in the liver

6

1 Down

0 Down

3 Down

5 Up

0 Up

1 Up

0 NS

6 NS

2 NS

Phosphatidylserine lipid (PS)

Role in cell signalling and apoptosis

1

1 Down

0 Down

0 Down

0 Up

0 Up

0 Up

0 NS

1 NS

1 NS

Sphingolipid (sm)

Cell surface protectant, cell signalling and recognition

15

8 Down

0 Down

0 Down

1 Up

3 Up

11 Up

6 NS

12 NS

4 NS

Phosphatidic lipid (PA)

Complex lipid building block and signalling

1

1 Down

0 Down

0 Down

0 Up

0 Up

1 Up

0 NS

1 NS

0 NS

Unclassified lipid (ul)

Various

76

31 Down

3 Down

24 Down

39 Up

11 Up

27 Up

6 NS

62 NS

25 NS

Small molecules

Various

57

26 Down

5 Down

17 Down

15 Up

6 Up

31 Up

16 NS

46 NS

9 NS